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Updated: Jul 14, 2025
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Experimental Strategies to Bridge Large Tissue Gaps in the Injured Spinal Cord after Acute and Chronic Lesion
Published on: April 5, 2016
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Hydrogel-based treatments for spinal cord injuries
Zhiqiang Jia1, Huanxuan Zeng1, Xiuzhi Ye1
1The Third Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325200, China.
Heliyon
|October 9, 2023
Summary
Hydrogels are promising biomaterials for treating spinal cord injury (SCI) due to their biocompatibility and drug-carrying capacity. This review explores hydrogel applications, methods, and future potential for SCI regeneration.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Neuroscience
Background:
- Spinal cord injury (SCI) causes significant neurological dysfunction.
- Current SCI treatments have limitations.
- Hydrogels offer biocompatibility and drug delivery capabilities for SCI therapy.
Purpose of the Study:
- To review hydrogel biomaterials for spinal cord injury (SCI) treatment.
- To discuss SCI anatomy, physiology, and existing treatment strategies.
- To analyze hydrogel crosslinking, classification, processing, and future applications.
Main Methods:
- Literature review of hydrogel applications in SCI.
- Discussion of SCI pathophysiology and treatment options.
- Analysis of hydrogel properties, preparation methods, and crosslinking techniques.
Main Results:
- Hydrogels are versatile biomaterials for SCI treatment, supporting drug and cell delivery.
- Various hydrogel types and processing methods exist for SCI regeneration.
- Electrical conductivity in some hydrogels aligns with neural tissue requirements.
Conclusions:
- Hydrogel biomaterials present novel therapeutic avenues for spinal cord injury (SCI).
- Further research into hydrogel applications can advance SCI treatment strategies.
- Development of advanced hydrogel therapies holds significant promise for SCI recovery.
