[Development of the pial microcirculatory system during ontogeny]

Area of Science:

• Neuroscience
• Physiology
• Developmental Biology

Context:

• Studies on the development of the central nervous system's vascular network.
• Understanding microcirculation in the context of brain development.
• Utilizing animal models for studying physiological processes.

Purpose:

• To investigate the key factors and developmental stages of the pial microcirculatory system in white rats.
• To characterize the temporal dynamics of blood flow and structural formation in the developing microvasculature.
• To explore the concept of structural-functional units in the ontogenesis of the pial microcirculatory system.

Summary:

• Biomicroscopic studies in anesthetized white rats identified increased cortex mass and microcirculatory bed formation as crucial for microcirculation development.
• Three distinct periods were observed: excessive primary capillary net blood flow (1-7 days), unstable flow with structure formation (7-30 days), and stable flow with stabilized construction (75-90 days).
• The research discusses the potential identification of structural-functional units within the pial microcirculatory system and their role in its ontogenetic development.

Impact:

• Provides a detailed timeline for the development of the pial microcirculation, essential for understanding brain development and potential interventions.
• Highlights the dynamic nature of microvascular development, with distinct phases of blood flow and structural organization.
• Contributes to the understanding of neurovascular development and the formation of functional units within the brain's microvasculature.