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Liposome-Based Antibacterial Delivery: An Emergent Approach to Combat Bacterial Infections
1Department of Organic Chemistry, Indian Institute of Science, Bangalore 560012, Karnataka, India.
Abstract:
The continued emergence and spread of drug-resistant pathogens and the decline in the approval of new antimicrobial drugs pose a major threat to managing infectious diseases, resulting in high morbidity and mortality. Even though a significant variety of antibiotics can effectively cure many bacterial infectious diseases, microbial infections remain one of the biggest global health problems, which may be due to the traditional drug delivery system's shortcomings which lead to poor therapeutic index, low drug absorption, and numerous other drawbacks. Further, the use of traditional antibiotics to treat infectious diseases has always been accompanied by the emergence of multidrug resistance and adverse side effects. Despite developing numerous new antibiotics, nanomaterials, and various techniques to combat infectious diseases, they have persisted as major global health issues. Improving the current antibiotic delivery systems is a promising approach to solving many life-threatening infections. In this context, nanoliposomal systems have recently attracted much attention. Herein, we attempt to provide a concise summary of recent studies that have used liposomal nanoparticles as delivery systems for antibacterial medicines. The minireview also highlights the enormous potential of liposomal nanoparticles as antibiotic delivery systems. The future of these promising approaches lies in developing more efficient delivery systems by precisely targeting bacterial cells with antibiotics with minimum cytotoxicity and high bacterial combating efficacy.
Insights
Drug-resistant infections are a major threat. Lipo-nanoparticle drug delivery systems show promise for improving antibiotic efficacy and reducing side effects, offering a new approach to combatting bacterial diseases.
Area of Science:
- Pharmaceutical Science
- Infectious Diseases
- Nanotechnology
Background:
- Drug-resistant pathogens and a lack of new antimicrobial drugs threaten global health.
- Traditional antibiotic delivery systems have limitations, including poor absorption and adverse effects, contributing to multidrug resistance.
- Despite advancements, infectious diseases remain a significant global health challenge.
Purpose of the Study:
- To summarize recent research on liposomal nanoparticles as delivery systems for antibacterial agents.
- To highlight the potential of liposomal nanoparticles in improving antibiotic therapy.
- To discuss future directions for enhanced antibiotic delivery systems.
Main Methods:
- Literature review of studies utilizing liposomal nanoparticles for antibiotic delivery.
- Analysis of the efficacy and limitations of current antibiotic delivery strategies.
- Exploration of nanoliposomal systems in combating bacterial infections.
Main Results:
- Liposomal nanoparticles are emerging as a promising strategy for delivering antibacterial medicines.
- These systems offer potential improvements over traditional delivery methods, addressing issues like poor therapeutic index and absorption.
- Recent studies demonstrate the capacity of liposomal nanoparticles to enhance antibiotic efficacy.
Conclusions:
- Improving antibiotic delivery systems is crucial for managing life-threatening infections.
- Liposomal nanoparticles show significant potential as advanced delivery vehicles for antibiotics.
- Future research should focus on targeted delivery with minimal cytotoxicity and high efficacy.
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