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Sarcopenia as an important determinant for adverse outcomes in patients with pyogenic liver abscess

Li Liu1,2, Shaohua Liu1,2, Meng Hao3

  • 1Department of Endocrinology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Peerj
|October 9, 2023
PubMed
Abstract

Insights

Sarcopenia, or low muscle mass, is an independent risk factor for poor prognosis in patients with pyogenic liver abscess (PLA). Patients with sarcopenia face a higher likelihood of adverse outcomes, highlighting its clinical significance.

Area of Science:

  • Hepatology
  • Geriatrics
  • Radiology

Background:

  • Low muscle mass (sarcopenia) is linked to poor prognosis in various diseases.
  • The clinical significance of sarcopenia in pyogenic liver abscess (PLA) is not well-established.
  • This study investigates the association between muscle mass and PLA patient prognosis.

Purpose of the Study:

  • To determine if sarcopenia is associated with adverse outcomes in patients with pyogenic liver abscess.
  • To evaluate the prognostic value of muscle mass indicators in PLA.

Main Methods:

  • Retrospective analysis of 154 adult PLA patients.
  • Muscle-fat indicators measured using CT scans at the L3 vertebral level.
  • Comparison between sarcopenia and non-sarcopenia groups using multivariate logistic regression and ROC curve analysis.

Main Results:

  • Skeletal muscle index (SMI) independently predicted adverse outcomes in PLA patients (95% CI [0.649-0.954], P=0.015).
  • ROC analysis showed SMI could predict adverse outcomes in both male (AUC=0.718) and female (AUC=0.714) populations.
  • Sex-specific cut-off values for SMI were identified for predicting adverse outcomes.

Conclusions:

  • Sarcopenia is an independent risk factor for poor prognosis in pyogenic liver abscess.
  • Patients with sarcopenia are at increased risk for adverse outcomes in PLA.
  • SMI is a valuable prognostic indicator in PLA patients.
Keywords:
Body compositionMuscle massPrognosisPyogenic liver abscessRetrospectiveSarcopenia

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