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Updated: Jul 14, 2025

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Does rDLPFC activity alter trust? Evidence from a tDCS study.

Letian Sun1,2, Xinbo Lu1,3, Haoli Zheng1,2

  • 1Center for Economic Behavior and Decision-Making (CEBD), Zhejiang University of Finance and Economics, Hangzhou, China.

Frontiers in Neuroscience
|October 9, 2023
PubMed
Summary

Transcranial direct current stimulation (tDCS) over the right dorsolateral prefrontal cortex (rDLPFC) causally influences trust behavior. Anodal stimulation, compared to sham, increased trust, highlighting the rDLPFC

Keywords:
causal relationshipdorsolateral prefrontal cortextranscranial direct current stimulationtrusttrust game

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Area of Science:

  • Neuroscience
  • Social Psychology
  • Behavioral Economics

Background:

  • Trust is fundamental to economic and social interactions.
  • The dorsolateral prefrontal cortex (DLPFC) is implicated in trust-related behaviors.
  • Limited research exists on the causal impact of DLPFC modulation on trust using tDCS.

Purpose of the Study:

  • To investigate the causal relationship between right DLPFC (rDLPFC) excitability and trust behavior.
  • To explore the effects of transcranial direct current stimulation (tDCS) on trust.
  • To provide empirical evidence for the role of the rDLPFC in trust.

Main Methods:

  • Utilized the classical trust game in multiple rounds.
  • Applied transcranial direct current stimulation (tDCS) over the rDLPFC.
  • Compared outcomes of anodal, cathodal, and sham stimulation.

Main Results:

  • Anodal rDLPFC stimulation significantly increased trust behavior compared to sham and cathodal stimulation.
  • Differential effects were observed across different stages of the trust game.
  • Established a causal link between rDLPFC activity and trust.

Conclusions:

  • rDLPFC excitability plays a causal role in modulating trust behavior.
  • tDCS over the rDLPFC offers a potential tool for investigating trust mechanisms.
  • Findings open new avenues for research at the intersection of neuroscience and social behavior.