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Relationship between homocysteine and chronic total coronary occlusion: a cross-sectional study from southwest China

Kaiyong Xiao1, Zhe Xv2, Liang Liu3

  • 1Department of Cardiology, Guangyuan Central Hospital, Guangyuan, SC, China.

Cardiology in the Young
|October 9, 2023
PubMed

Insights

Elevated homocysteine levels are significantly linked to chronic total coronary occlusion, a complex heart condition. This association is particularly strong in older individuals and those with diabetes or hypertension.

Area of Science:

  • Cardiology
  • Biochemistry
  • Public Health

Background:

  • Chronic total coronary occlusion (CTO) represents a complex challenge in cardiovascular medicine.
  • Elevated homocysteine is a known risk factor for coronary artery diseases, but its specific role in CTO requires further investigation.

Purpose of the Study:

  • To investigate the association between homocysteine levels and the prevalence of chronic total coronary occlusion in a Chinese population.
  • To identify whether homocysteine is an independent risk factor for CTO.

Main Methods:

  • A study involving 1295 individuals from Southwest China.
  • Analysis of homocysteine levels divided into quartiles, with CTO defined as >3 months of complete coronary artery occlusion.
  • Statistical methods included logistic regression, ROC curves, and subgroup analyses.

Main Results:

  • Higher homocysteine quartiles correlated with increased rates of CTO (P < 0.001).
  • Elevated homocysteine (≥ 15.2 μmol/L) was an independent predictor of CTO (OR 1.53, P=0.0265).
  • The association was more pronounced in elderly individuals and those with hypertension and diabetes.

Conclusions:

  • Elevated homocysteine is significantly associated with chronic total coronary occlusion.
  • Homocysteine serves as an independent indicator for CTO, especially in vulnerable subgroups like the elderly and patients with comorbidities.
Abstract

Keywords:
Coronary artery diseasechronic total coronary occlusioncoronary occlusionhomocysteinehyperhomocysteinemia

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