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Updated: Jun 20, 2026
06:35
Visualization of Craniofacial Development in the sox10: kaede Transgenic Zebrafish Line Using Time-lapse Confocal Microscopy
Published on: September 30, 2013
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Craniofacial developmental biology in the single-cell era
Kuo-Chang Tseng1, J Gage Crump1
1Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine of University of Southern California, Los Angeles, CA 90033, USA.
Development (Cambridge, England)
|October 9, 2023
Summary
New single-cell technologies reveal the genetic and regulatory elements guiding vertebrate head development. This research deepens our understanding of craniofacial structures and congenital anomalies.
Area of Science:
- Developmental Biology
- Genetics
- Evolutionary Biology
Background:
- Vertebrate craniofacial development involves complex interactions between germ layers and cranial neural crest.
- Decades of research have identified genes and pathways, but the role of non-coding genomic elements in craniofacial development and disease remains unclear.
Conclusions:
- Emerging single-cell technologies are revolutionizing the study of craniofacial development.
- Understanding non-coding genomic elements is crucial for deciphering craniofacial anomalies.
- Further in vivo validation is essential to fully leverage these new insights into vertebrate head development and disease.
Keywords:
Congenital anomaliesCranial neural crestCraniofacialSingle-cell genomicsVertebrate head developmentMore Related Videos
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