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Updated: Jul 14, 2025

Enzymatic Synthesis of Epoxidized Metabolites of Docosahexaenoic, Eicosapentaenoic, and Arachidonic Acids
Published on: June 28, 2019
Natural epoxyquinoids: isolation, biological activity and synthesis. An update
Vitaly A Shcherbinin1, Ekaterina R Nasibullina2, Elena Y Mendogralo2
1N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Pr. 47, 119334 Moscow, Russian Federation.
Abstract:
Epoxyquinoids are of continuing interest due to their wide natural distribution and diverse biological activities, including, but not limited to, antibacterial, antifungal, anticancer, enzyme inhibitory, and others. The last review on their total synthesis was published in 2017. Since then, almost 100 articles have been published on their isolation from nature and their biological profile. In addition, the review specifically considers synthesis, including total and enantioselective, as well as the development of shorter approaches for the construction of epoxyquinoids with complex chemical architecture. Thus, this review focuses on progress in this area in order to stimulate further research.
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