Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Two-disease locus model: sib pair method using information on both HLA and Gm.

M H Dizier, F Clerget-Darpoux

    Genetic Epidemiology
    |January 1, 1986
    PubMed
    Summary

    This study introduces a new sib pair method to test if the transmission of Gm and disease are independent. It analyzes the joint distribution of HLA and Gm in affected sibling pairs to detect their combined effects.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Network-assisted analysis of GWAS data identifies a functionally-relevant gene module for childhood-onset asthma.

    Scientific reports·2017
    Same author

    Genetics of emotional reactivity in bipolar disorders.

    Journal of affective disorders·2015
    Same author

    Progeny group size for evaluating natural service bulls using AI reference sires.

    Annales de genetique et de selection animale·2012
    Same author

    Season of birth and not vitamin D receptor promoter polymorphisms is a risk factor for multiple sclerosis.

    Multiple sclerosis (Houndmills, Basingstoke, England)·2009
    Same author

    HLA-DRB1*15 allele influences the later course of relapsing remitting multiple sclerosis.

    Genes and immunity·2008
    Same author

    No evidence for association between the EIF2B5 gene and multiple sclerosis in French families.

    Multiple sclerosis (Houndmills, Basingstoke, England)·2008

    Area of Science:

    • Genetics
    • Immunogenetics
    • Statistical Genetics

    Background:

    • The human leukocyte antigen (HLA) complex and the Gm allotypes are important genetic systems influencing various diseases.
    • Understanding the independent or joint effects of these genetic markers is crucial for disease association studies.

    Purpose of the Study:

    • To adapt the sib pair method for assessing the independence of Gm transmission and disease.
    • To derive the joint distribution of HLA and Gm in affected sib pairs under various two-locus models.
    • To propose a statistical test for the joint effect of HLA and Gm, including non-multiplicative interactions.

    Main Methods:

    • Adaptation of the sib pair method using a variable (X) for Gm phenotypic identity.
    • Derivation of the joint distribution of identity by descent (IBD) for HLA and Gm.

    Related Experiment Videos

  • Analysis under multiplicative and other two-locus models with strict linkage.

    • Main Results:

    • A method is presented to test the independence of Gm transmission and disease.
    • The joint distribution of HLA and Gm among affected sib pairs was derived.
    • A test for joint and potentially non-multiplicative effects of HLA and Gm was developed.

    Conclusions:

    • The adapted sib pair method allows for the investigation of genetic associations with Gm and disease.
    • The derived joint distributions and proposed tests facilitate the analysis of complex genetic interactions between HLA and Gm loci.
    • This approach aids in understanding the combined genetic contribution of HLA and Gm to disease susceptibility.