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Updated: Jul 14, 2025

In Vitro Differentiation of Human Pluripotent Stem Cells into Trophoblastic Cells
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Using human pluripotent stem cells to dissect trophoblast development.

Daisuke Suzuki1, Kuan-Chun Lan1, Yasuhiro Takashima1

  • 1Center for iPS Cell Research and Application, Kyoto University, 53 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto 606-8507, Japan.

Current Opinion in Genetics & Development
|October 9, 2023
PubMed
Summary
This summary is machine-generated.

Naive human pluripotent stem cells (PSCs) can differentiate into trophoblasts, offering insights into early human development. This review explores trophoblast differentiation pathways from both naive and primed human PSCs in vitro.

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Area of Science:

  • Developmental Biology
  • Stem Cell Biology
  • Reproductive Biology

Background:

  • Human pluripotent stem cells (PSCs) exist in naive and primed states, exhibiting distinct developmental potentials.
  • Trophoblast development is crucial for blastocyst formation and implantation.
  • Previous studies demonstrated trophoblast differentiation from primed PSCs.

Purpose of the Study:

  • To review the in vitro differentiation of trophoblasts from human PSCs.
  • To compare trophoblast differentiation pathways from naive and primed human PSCs.
  • To discuss the implications for understanding in vivo trophoblast development.

Main Methods:

  • Review of existing literature on human PSC differentiation into trophoblasts.
  • Analysis of in vitro models for trophoblast specification.
  • Comparative discussion of naive and primed PSC differentiation protocols.

Main Results:

  • Naive human PSCs can differentiate into trophoblasts via trophectoderm (TE)-like cells.
  • TE represents a pre-implantation stage of trophoblast development.
  • In vitro differentiation suggests potential for in vivo trophoblast potential from epiblasts.

Conclusions:

  • Human PSCs are valuable tools for studying trophoblast development.
  • Distinct pathways exist for trophoblast differentiation from naive and primed PSCs.
  • Understanding these pathways aids in studying early human embryogenesis and implantation.