Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Positron Emission Tomography01:29

Positron Emission Tomography

4.2K
Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
4.2K
Transmission Electron Microscopy01:15

Transmission Electron Microscopy

5.6K
In 1931, physicist Ernst Ruska—building on the idea that magnetic fields can direct an electron beam just as lenses can direct a beam of light in an optical microscope—developed the first prototype of the electron microscope. This development led to the development of the field of electron microscopy. In the transmission electron microscope (TEM), electrons are produced by a hot tungsten element and accelerated by a potential difference in an electron gun, which gives them up to 400...
5.6K
Computed Tomography01:10

Computed Tomography

4.6K
Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
4.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

First look at neutron emission shape characteristics of ignition hotspots at the National Ignition Facility (invited).

The Review of scientific instruments·2024
Same author

Source shape estimation for neutron imaging systems using convolutional neural networks.

The Review of scientific instruments·2024
Same author

Source localization for neutron imaging systems using convolutional neural networks.

The Review of scientific instruments·2024
Same author

Efficient Synthesis and HPLC-Based Characterization for Developing Vanadium-48-Labeled Vanadyl Acetylacetonate as a Novel Cancer Radiotracer for PET Imaging.

Molecules (Basel, Switzerland)·2024
Same author

Frailty as a predictor of postoperative outcomes in neurosurgery: a systematic review.

Journal of neurosurgical sciences·2023
Same author

Accelerator-Based Production of Scandium Radioisotopes for Applications in Prostate Cancer: Toward Building a Pipeline for Rapid Development of Novel Theranostics.

Molecules (Basel, Switzerland)·2023

Related Experiment Video

Updated: Jul 14, 2025

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

20.4K

A TOPAS model for lens-based proton radiography.

Brittany A Broder1, Ethan F Aulwes2, Michelle Espy2

  • 1The University of Chicago, 5841 South Ellis Avenue, Chicago, IL 60637, United States of America.

Biomedical Physics & Engineering Express
|October 9, 2023
PubMed
Summary

Proton radiography shows promise for medical imaging, offering improved contrast with high-Z materials and better resolution at higher energies. This technique is viable for visualizing bone structures and could be integrated into carbon therapy centers.

Keywords:
coulomb scatteringmagnetic lensproton radiography

More Related Videos

Lensfree On-chip Tomographic Microscopy Employing Multi-angle Illumination and Pixel Super-resolution
08:41

Lensfree On-chip Tomographic Microscopy Employing Multi-angle Illumination and Pixel Super-resolution

Published on: August 16, 2012

11.6K
Dynamic Pore-scale Reservoir-condition Imaging of Reaction in Carbonates Using Synchrotron Fast Tomography
10:18

Dynamic Pore-scale Reservoir-condition Imaging of Reaction in Carbonates Using Synchrotron Fast Tomography

Published on: February 21, 2017

8.5K

Related Experiment Videos

Last Updated: Jul 14, 2025

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies
08:34

Proton Therapy Delivery and Its Clinical Application in Select Solid Tumor Malignancies

Published on: February 6, 2019

20.4K
Lensfree On-chip Tomographic Microscopy Employing Multi-angle Illumination and Pixel Super-resolution
08:41

Lensfree On-chip Tomographic Microscopy Employing Multi-angle Illumination and Pixel Super-resolution

Published on: August 16, 2012

11.6K
Dynamic Pore-scale Reservoir-condition Imaging of Reaction in Carbonates Using Synchrotron Fast Tomography
10:18

Dynamic Pore-scale Reservoir-condition Imaging of Reaction in Carbonates Using Synchrotron Fast Tomography

Published on: February 21, 2017

8.5K

Area of Science:

  • Medical Physics
  • Radiological Imaging
  • Particle Therapy

Background:

  • Proton radiography offers potential for patient positioning, real-time stopping power estimation, and adaptive therapy.
  • Monte Carlo simulations using TOPAS enable advanced modeling of proton and heavy ion treatments and imaging.

Purpose of the Study:

  • To evaluate lens-based proton radiography as an instantaneous imaging technique.
  • To model the magnetic lens system at LANSCE for proton radiography simulations.
  • To assess image quality and contrast at various proton energies and collimation levels.

Main Methods:

  • Modeled a four-quadrupole magnetic lens system in TOPAS for an 800-MeV proton beamline.
  • Simulated imaging of various objects at energies from 230-930 MeV with different collimator settings.
  • Scaled magnetic field strength with particle relativistic factor (βγ).

Main Results:

  • High-Z materials (gold, gallium, bone) provided greater contrast than low-Z materials (water, lung).
  • A 5-mrad collimator enhanced tissue-to-contrast agent contrast; a 10-mrad collimator improved differentiation of high-Z materials.
  • Image quality improved with energy, achieving sub-mm resolution at 630 MeV, though water-equivalent path length required calibration.

Conclusions:

  • Proton radiography is viable for shallow bone imaging at 330 MeV and deeper structures at 630 MeV.
  • High-Z contrast agents enhance visibility, making the modality suitable for carbon therapy centers.
  • The developed TOPAS model supports advanced simulations for proton therapy and particle imaging.