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Rapid Development of Cell State Identification Circuits with Poly-Transfection
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Cell jamming-to-unjamming transitions and vice versa in development: Physical aspects
Ivana Pajic-Lijakovic1, Milan Milivojevic1
1Faculty of Technology and Metallurgy, Belgrade University, Karnegijeva 4, Belgrade, Serbia.
Bio Systems
|October 9, 2023
Summary
Collective cell migration involves epithelial cells jamming and unjamming, a phenomenon distinct from epithelial-to-mesenchymal transition. This study explores the physical origins of epithelial jamming and unjamming.
Area of Science:
- Cell Biology
- Biophysics
- Developmental Biology
Background:
- Collective cell migration is crucial for morphogenesis, wound healing, and cancer metastasis.
- Epithelial cell collectives often exhibit jamming behavior, pausing migration, unlike mesenchymal collectives.
- The mechanism behind epithelial jamming and unjamming remains unclear and is not epithelial-to-mesenchymal transition.
Purpose of the Study:
- To investigate the underlying physical factors causing epithelial cell collectives to jam and unjam.
- To elucidate the relationship between cell-cell adhesion, contractility, and collective cell migration dynamics.
Main Methods:
- Theoretical modeling of cell-cell adhesion and contractility.
- Analysis of physical factors like compressive residual stress accumulation.
- Examination of surface characteristics of jamming and unjamming epithelial clusters.
Main Results:
- Identified cell-cell adhesion strength and cell contractility as key determinants of jamming/unjamming.
- Linked compressive residual stress accumulation to the jamming phenomenon in epithelial collectives.
- Characterized surface properties differentiating migrating (unjamming) from resting (jamming) epithelial clusters.
Conclusions:
- Epithelial jamming/unjamming is driven by physical factors including cell-cell adhesion and contractility.
- Understanding these physical origins is key to controlling collective cell migration.
- This research provides a theoretical framework for the jamming/unjamming of epithelial collectives.
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