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Risk Factors and Location of Intracranial Aneurysm Rupture in a Consecutive Chinese Han Population

Xiaopeng Cui1, Liang Wang2, Yan Zhao3

  • 1Department of Neurosurgery, Tianjin Fifth Central Hospital, Tianjin, China; Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China.

World Neurosurgery
|October 9, 2023
PubMed

Insights

Intracranial aneurysm (IA) location is the primary predictor of rupture, with anterior and posterior communicating arteries posing the highest risk. Conditions like hyperlipidemia and atherosclerosis appear to reduce rupture risk.

Area of Science:

  • Neurosurgery
  • Vascular Neurology
  • Radiology

Background:

  • Intracranial aneurysms (IAs) affect a significant patient population, with rupture leading to subarachnoid hemorrhage.
  • Understanding risk factors for IA rupture is crucial for clinical management and prevention strategies.

Purpose of the Study:

  • To retrospectively analyze clinical data of 704 patients with ruptured intracranial aneurysms (RIAs) and unruptured intracranial aneurysms (UIAs).
  • To identify clinical characteristics and risk factors associated with IA rupture.

Main Methods:

  • Retrospective analysis of 704 patients (494 RIA, 210 UIA) between 2016 and 2022.
  • Clinical data including demographics, medical history, and aneurysm location were analyzed.
  • Logistic regression was employed to determine predictors of aneurysm rupture.

Main Results:

  • IA location was the most significant predictor of rupture (e.g., anterior communicating artery OR 27.86, posterior communicating artery OR 12.41).
  • Hyperlipidemia, atherosclerosis, and multiple aneurysms were associated with a lower likelihood of rupture (ORs < 0.4).
  • Age was not a significant predictor in the logistic regression model.

Conclusions:

  • IA location is a critical determinant of rupture risk, with specific sites like the anterior and posterior communicating arteries being high-risk.
  • Hyperlipidemia and atherosclerosis may confer a protective effect against IA rupture.
  • The findings highlight the importance of anatomical location in predicting aneurysm rupture.
Abstract

Keywords:
Clinical factorsIntracranial aneurysmLocationRisk factors

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