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Circulating immune complexes in sickle cell anaemia
Circulating immune complexes were investigated in sera of 100 patients with sickle cell anaemia (SCA) in different clinical stages, using inhibition of complement-dependent rosette formation (EAC rosette inhibition), anticomplementary activity, polyethylene glycol 6000 precipitation, immunoconglutinin titre, total haemolytic complement, C4 and C3d. A high positivity was observed in patients with hepatic crisis (75%) and cases with leg ulcers (43%) compared with painful crisis (12%) and asymptomatic (7%) patients. These results provide evidence for the presence of circulating immune complexes during leg ulcers and hepatic crisis in SCA.
Circulating immune complexes were investigated in sera of 100 patients with sickle cell anaemia (SCA) in different clinical stages, using inhibition of complement-dependent rosette formation (EAC rosette inhibition), anticomplementary activity, polyethylene glycol 6000 precipitation, immunoconglutinin titre, total haemolytic complement, C4 and C3d. A high positivity was observed in patients with hepatic crisis (75%) and cases with leg ulcers (43%) compared with painful crisis (12%) and asymptomatic (7%) patients. These results provide evidence for the presence of circulating immune complexes during leg ulcers and hepatic crisis in SCA.