Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Structure-activity relationships in allergic contact dermatitis.

B F Goodwin, D W Roberts

    Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
    |June 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Neutron Rem Detector Response Changes due to Activation of Components.

    Health physics·2018
    Same author

    An evaluation of selected (Q)SARs/expert systems for predicting skin sensitisation potential.

    SAR and QSAR in environmental research·2018
    Same author

    Riboflavin induces Metarhizium spp. to produce conidia with elevated tolerance to UV-B, and upregulates photolyases, laccases and polyketide synthases genes.

    Journal of applied microbiology·2018
    Same author

    Cigarette smoking is associated with an altered vaginal tract metabolomic profile.

    Scientific reports·2018
    Same author

    The impact of electrolyte on the adsorption of the anionic surfactant methyl ester sulfonate at the air-solution interface: Surface multilayer formation.

    Journal of colloid and interface science·2017
    Same author

    Hyperspectral data processing improves PpIX contrast during fluorescence guided surgery of human brain tumors.

    Scientific reports·2017
    Same journal

    Integrated Whole-Transcriptome Analysis Reveals ceRNA Network Dysregulation underlying Methcathinone-induced Synaptic Damage and Cognitive Impairment.

    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·2026
    Same journal

    Unveiling the Semi Volatile Composition and Nicotine/Myosmine Release Dynamics of Novel Oral Nicotine Pouches.

    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·2026
    Same journal

    Alcohol and High-Fat Diet Aggravate Colitis-Induced Liver Injury via Glucocorticoid/IL-6-SAA1 Axis in Mice.

    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·2026
    Same journal

    The combined effect of early-life Bisphenol A (BPA) exposure and post-weaning high-fat diet on the intestinal health of mice.

    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·2026
    Same journal

    Developmental reproductive impacts of gestational polystyrene nanoplastics exposure: precocious puberty and impaired ovarian reserve in female offspring.

    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·2026
    Same journal

    Alternariol, a mycotoxin, induces oxidative stress, inflammation, and apoptosis in human astrocytes: Protective effects of eicosapentaenoic acid.

    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association·2026
    See all related articles

    Simple chemicals cause skin sensitization by reacting with proteins, forming allergenic determinants. The Relative Alkylation Index (RAI) theory quantifies this for alkylating agents, aiding reactivity and cross-reactivity predictions.

    Area of Science:

    • Toxicology
    • Dermatology
    • Chemical Reactivity

    Background:

    • Skin sensitization is an immunological response to simple chemicals.
    • Chemicals react with skin proteins to form haptenic groups, acting as allergenic determinants.
    • Understanding chemical reactivity is crucial for predicting sensitization potential.

    Purpose of the Study:

    • To present a quantitative model, the Relative Alkylation Index (RAI) theory, for chemical sensitization.
    • To apply the RAI theory to model compounds like p-nitrobenzyl halides and sultones.
    • To explore the use of chemical structure analysis for predicting skin protein reactivity and cross-reactivity.

    Main Methods:

    • Development and application of the Relative Alkylation Index (RAI) theory.
    • Analysis of chemical structures of p-nitrobenzyl halides, saturated sultones, and unsaturated sultones.

    Related Experiment Videos

  • Evaluation of chemical reaction types to predict protein interactions.

    • Main Results:

    • The RAI theory provides a quantitative measure for sensitization by alkylating agents.
    • Model compound series demonstrated the applicability of the RAI theory.
    • Chemical structure examination effectively predicts reactivity and cross-reactivity with skin proteins.

    Conclusions:

    • Chemical structure analysis is a valuable tool for assessing sensitization potential and cross-reactivity.
    • The RAI theory offers a framework for understanding and predicting skin sensitization by reactive chemicals.
    • The pro-hapten concept explains sensitization by pre-reactive compounds and cross-reactions.