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IL-13 neutralization attenuates carotid artery intimal hyperplasia and increases endothelial cell migration via

Qi Li1, Yue Li2, Fengjiao Wu1

  • 1The Biotherapy Center, Tumor Hospital of Harbin Medical University, Harbin, P. R. China.

Cell Adhesion & Migration
|October 10, 2023
PubMed

The aim of this study was to investigate how the concentration of interleukin-13 (IL-13) affects the regulation of endothelial cell migration after injury. The incubation of recombinant human interleukin-13 (rhIL-13) strongly increased the content of reactive oxygen species (ROS) in HUVECs via the JAK-1/STAT-3/NOX-4 signaling pathway. Antagonizing the high intracellular ROS that was induced by rhIL-13 promoted the migration of HUVECs. Furthermore, IL-13 neutralization not only inhibited intimal hyperplasia, but also promoted the migration of endothelial cells (ECs) after injury. The results suggest that IL-13 inhibition is a potential means of stimulating endothelial cells recovery after injury. Therefore, the attenuation of IL-13 activation may have therapeutic value for vascular disease.

Keywords:
Endothelial cellsIL-13STAT-3intimal hyperplasiareactive oxygen species

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