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Author Spotlight: A Comprehensive Protocol for Acinetobacter Biofilm Quantification, Assessment, and Visualization
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Clinical impact of COVID-19 in patients with carbapenem-resistant Acinetobacter baumannii bacteraemia

Jeong Yeon Kim1, Woo Joo Lee1, Jin Woong Suh1

  • 1Division of Infectious Diseases, Department of Internal Medicine, Korea University College of Medicine, Seoul, Republic of Korea.

Epidemiology and Infection
|October 10, 2023
PubMed

Insights

Coronavirus disease 2019 (COVID-19) negatively impacts critically ill patients with carbapenem-resistant Acinetobacter baumannii (CRAB) bloodstream infections. COVID-19 diagnosis was a significant predictor of increased 28-day mortality in these vulnerable patients.

Area of Science:

  • Infectious Diseases
  • Critical Care Medicine
  • Microbiology

Background:

  • Carbapenem-resistant Acinetobacter baumannii (CRAB) poses a significant threat to critically ill patients.
  • The impact of concurrent coronavirus disease 2019 (COVID-19) on CRAB bloodstream infection (BSI) outcomes is not well understood.

Purpose of the Study:

  • To evaluate the effect of COVID-19 on treatment outcomes in critically ill patients with CRAB BSI.
  • To identify predictors of mortality in this patient population.

Main Methods:

  • Retrospective cohort study of 70 adult ICU patients with CRAB BSI from January 2021 to March 2022.
  • Analysis included patients with and without COVID-19 diagnosis.
  • Multivariate Cox proportional hazard regression was used to identify mortality predictors.

Main Results:

  • 24 (34.3%) patients had a COVID-19 diagnosis.
  • The overall 28-day mortality rate was 64.3%.
  • COVID-19 diagnosis (HR 2.91), neutropenia (HR 2.76), and Pitt bacteraemia score (HR 1.30) were independent predictors of 28-day mortality. Appropriate antibiotic therapy was protective (HR 0.31).

Conclusions:

  • COVID-19 has a negative prognostic impact on patients with CRAB BSI.
  • Further research is required to elucidate the mechanisms by which COVID-19 exacerbates CRAB infection outcomes.

Keywords:
Acinetobacter baumanniiSARS-CoV-2carbapenem resistancecoronavirus disease 2019mortality

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