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Related Experiment Video

Updated: Jul 14, 2025

Experimental Generation of Carcinoma-Associated Fibroblasts CAFs from Human Mammary Fibroblasts

Experimental Generation of Carcinoma-Associated Fibroblasts CAFs from Human Mammary Fibroblasts

Published on: October 25, 2011

[Atypical fibroxanthoma].

N V Vasilyev¹, S V Vtorushin^1,2, A A Maltseva¹

¹Cancer Research Institute of Tomsk National Research Medical Center, Tomsk, Russia.

Arkhiv Patologii

|October 10, 2023

Summary

Atypical fibroxanthoma (AFX) is a rare skin tumor with malignant features but a non-aggressive course. This review details its diagnosis, characteristics, and subtypes.

Keywords:

atypical fibroxanthoma characteristics diagnosis histology immunohistochemistry prognosis

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Area of Science:

Dermatology
Oncology
Pathology

Context:

Atypical fibroxanthoma (AFX) presents diagnostic challenges due to its "malignant" morphological features and heterogeneous immunophenotype, despite a typically non-aggressive clinical course.
Understanding the nuances of AFX is crucial for accurate diagnosis and patient management in dermatopathology.

Purpose:

To provide a comprehensive overview of Atypical fibroxanthoma (AFX), covering its historical context, histogenesis, and pathogenesis.
To detail the clinical, morphological, immunohistochemical, molecular cytogenetic, and histological characteristics of AFX.
To elucidate the differential diagnosis of AFX, aiding clinicians and pathologists.

Summary:

This review consolidates current knowledge on Atypical fibroxanthoma (AFX), a rare skin neoplasm.
It explores the evolution of AFX as a distinct cancer entity, its origins, and biological potential.
Detailed descriptions of AFX subtypes, diagnostic markers, and differential diagnostic considerations are included.

Impact:

Enhances understanding of a rare skin tumor with complex diagnostic criteria.
Provides a valuable resource for dermatologists, pathologists, and oncologists managing AFX.
Aims to improve diagnostic accuracy and inform treatment strategies for Atypical fibroxanthoma.