Real-time water/fat imaging at 0.55T with spiral out-in-out-in sampling

To develop an efficient and flexible water/fat separated real-time MRI (RT-MRI) method using spiral out-in-out-in (OIOI) sampling and balanced SSFP (bSSFP) at 0.55T.

A bSSFP sequence with golden-angle spiral OIOI readout was developed, capturing three echoes to allow water/fat separation. A low-latency reconstruction that combines all echoes was available for online visualization. An offline reconstruction provided water and fat RT-MRI in two steps: (1) image reconstruction with spatiotemporally constrained reconstruction (STCR) and (2) water/fat separation with hierarchical iterative decomposition of water and fat with echo asymmetry and least-squares estimation (HIDEAL). In healthy volunteers, spiral OIOI was acquired in the wrist during a radial-to-ulnar deviation maneuver, in the heart without breath-hold and cardiac gating, and in the lower abdomen during free-breathing for visualizing small bowel motility.

We demonstrate successful water/fat separated RT-MRI for all tested applications. In the wrist, resulting images provided clear depiction of ligament gaps and their interactions during the radial-to-ulnar deviation maneuver. In the heart, water/fat RT-MRI depicted epicardial fat, provided improved delineation of epicardial coronary arteries, and provided high blood-myocardial contrast for ventricular function assessment. In the abdomen, water-only RT-MRI captured small bowel mobility clearly with improved water-fat contrast.

We have demonstrated a novel and flexible bSSFP spiral OIOI sequence at 0.55T that can provide water/fat separated RT-MRI with a variety of application-specific temporal resolution and spatial resolution requirements.