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In men aged young to middle, hyperestrogenia (HE) significantly increased the likelihood of developing arterial hypertension. However, overall cardiovascular disease risk scores did not differ between men with and without HE.

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Area of Science:

  • Endocrinology
  • Cardiology
  • Men's Health

Background:

  • Elevated serum estradiol levels, a condition known as hyperestrogenia (HE), are increasingly recognized in men.
  • The association between HE and cardiovascular risk factors in young and middle-aged men requires further investigation.

Purpose of the Study:

  • To investigate the relationship between cardiovascular risk and estradiol levels in young and middle-aged men.
  • To determine if HE is associated with specific cardiovascular risk factors and overall cardiovascular disease risk.

Main Methods:

  • A cohort of 71 men with newly diagnosed HE (serum estradiol >41.2 pg/mL) was compared to 68 age- and body weight index (BWI)-matched controls with normal estradiol levels.
  • Measurements included anthropometrics, bioimpedance, blood pressure (BP), and serum concentrations of estradiol, testosterone, glucose, and total cholesterol.
  • The probability of arterial hypertension and overall cardiovascular risk using the SCORE scale were assessed.

Main Results:

  • Men with HE exhibited significantly lower testosterone levels (p=0.006) and higher systolic (p=0.011) and diastolic (p=0.008) blood pressure compared to controls.
  • Total cholesterol levels were also significantly higher in the HE group (p=0.023).
  • Hyperestrogenia was found to be an independent predictor, increasing the likelihood of arterial hypertension by 2.11 times (p=0.038).

Conclusions:

  • In young and middle-aged men, hyperestrogenia is an independent predictor of arterial hypertension.
  • Despite associations with hypertension and altered cholesterol, overall cardiovascular disease risk calculated by the SCORE scale did not significantly differ between groups.