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Farnesoid X receptor: From Structure to Function and Its Pharmacology in Liver Fibrosis

Chuan Ding1,2, Zeping Wang1, Xinyue Dou1

  • 1School of Pharmacy, Zhejiang Chinese Medical University, Hangzhou, China.

Aging and Disease
|October 10, 2023
PubMed

Insights

Farnesoid X receptor (FXR) shows promise for treating liver fibrosis by modulating bile acid metabolism. Research highlights FXR’s potential in combating liver disease progression and improving therapeutic options.

Area of Science:

  • Hepatology
  • Molecular Biology
  • Pharmacology

Background:

  • The farnesoid X receptor (FXR) regulates bile acid metabolism and impacts liver health.
  • Liver fibrosis, a precursor to cirrhosis and cancer, has limited FDA-approved treatments.
  • FXR is involved in metabolic disorders, immune function, and liver disease.

Purpose of the Study:

  • To review recent advancements in farnesoid X receptor (FXR) research for liver fibrosis.
  • To explore the potential pharmacological role of FXR in treating hepatic fibrosis.
  • To highlight challenges and mechanisms of FXR in liver fibrosis treatment.

Main Methods:

  • Review of recent fundamental research and clinical investigations on FXR.
  • Analysis of FXR's structure and its implications for drug development.
  • Examination of FXR's role in bile acid metabolism and liver disease progression.

Main Results:

  • FXR plays a critical role in enterohepatic circulation and liver homeostasis.
  • Recent studies reveal FXR's potential as a therapeutic target for liver fibrosis.
  • Progress in understanding FXR's mechanisms offers new avenues for treatment.

Conclusions:

  • FXR is a promising target for developing novel therapies for liver fibrosis.
  • Further research into FXR mechanisms can overcome current therapeutic limitations.
  • Targeting FXR may offer a new strategy to manage liver disease progression.

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