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Mitochondria: A Potential Rejuvenation Tool against Aging

Qian Hua Phua1,2, Shi Yan Ng1,3,4, Boon-Seng Soh1,2

  • 1Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), Proteos, Singapore.

Aging and Disease
|October 10, 2023
PubMed

Insights

This review explores anti-aging strategies, focusing on mitotherapy to combat aging and cellular decline. Mitochondrial transplantation shows promise in animal models and clinical trials for counteracting aging.

Area of Science:

  • Gerontology and Cellular Biology
  • Mitochondrial Medicine
  • Regenerative Medicine

Background:

  • Aging is characterized by physiological and cognitive decline, driven by multiple hallmarks and pathways.
  • Increased life expectancy fuels research into anti-aging therapies and pharmacological interventions.
  • Mitochondrial dysfunction is a key factor in aging, impacting cellular health.

Purpose of the Study:

  • To review current anti-aging strategies.
  • To highlight mitotherapy as a novel approach to counteract aging.
  • To examine the translational potential of mitochondrial transplantation.

Main Methods:

  • Literature review of anti-aging strategies.
  • Focus on mitotherapy and mitochondrial transplantation.
  • Analysis of studies in animal models and clinical trials.

Main Results:

  • Mitotherapy presents a promising strategy against aging.
  • Mitochondrial transplantation has demonstrated success in preclinical and clinical settings.
  • The review synthesizes current knowledge on mitotherapy's application.

Conclusions:

  • Mitotherapy holds significant potential for anti-aging interventions.
  • Mitochondrial transplantation is a viable therapeutic avenue.
  • Further research is needed to address challenges and explore future possibilities in mitotherapy for aging.

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