Related Experiment Video
Updated: Jul 14, 2025
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Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis
Published on: January 29, 2016
16.9K
Feasibility of Low-Load Resistance Training Using Blood Flow Restriction for People With Advanced Multiple Sclerosis:
Mark M Mañago1,2,3, Evan T Cohen4, Enrique Alvarez2
1Physical Therapy Program, Department of Physical Medicine and Rehabilitation, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Physical Therapy
|October 10, 2023
Summary
Low-load resistance training with blood flow restriction (BFR) is feasible for individuals with advanced multiple sclerosis (MS). This approach may offer an alternative for those unable to tolerate higher intensity exercise due to severe symptoms.
Area of Science:
- Neurology
- Rehabilitation Medicine
- Exercise Physiology
Background:
- Multiple Sclerosis (MS) is a chronic neurological disease causing progressive disability.
- Individuals with advanced MS (EDSS 6.0-7.0) often experience severe symptoms like fatigue and weakness, limiting exercise tolerance.
- Conventional moderate- to high-intensity training may be unsuitable for this population.
Purpose of the Study:
- To assess the feasibility of low-load resistance training combined with blood flow restriction (BFR) in individuals with advanced MS.
- To evaluate safety, adherence, and participant satisfaction with the BFR intervention.
- To explore preliminary effects on muscle strength and functional outcomes.
Main Methods:
- A prospective cohort study involving 14 participants with MS (EDSS 6.0-7.0).
- Participants performed lower extremity resistance exercises with BFR twice weekly for 8 weeks.
- Feasibility was assessed by enrollment, retention, adherence, satisfaction, and adverse events. Functional outcomes and muscle strength were also measured.
Main Results:
- The intervention demonstrated high feasibility with 93% adherence and high participant satisfaction.
- A single minor hip muscle strain was the only intervention-related adverse event.
- Significant improvements were observed in muscle strength, 30-Second Sit-to-Stand Test, Berg Balance Scale, and Patient-Specific Functional Scale. Reductions in Modified Fatigue Impact Scale scores were also noted.
Conclusions:
- Low-load resistance training with BFR is a feasible and safe intervention for individuals with advanced MS and significant disability.
- The findings suggest that BFR training may be a viable option for MS patients who cannot tolerate conventional exercise intensities.
- Further research into the efficacy of BFR in improving functional capacity and reducing symptoms in MS is warranted.
