Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

14
Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
14
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

11
Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
11
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

15
Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
15

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Escalation Strategies in Cardiogenic Shock: From Early Recognition to Advanced Support.

Cardiology clinics·2026
Same author

Are Lung Allografts From Drug Overdose Deaths Safe to Use for Transplantation? A Nationwide Analysis.

Annals of thoracic surgery short reports·2026
Same author

Variation in Vasoactive Treatment Selection for Cardiogenic Shock: Insights From the Critical Care Cardiology Trials Network (CCCTN).

Circulation. Heart failure·2026
Same author

Microaxial Flow Pumps in Heart Failure-Related Cardiogenic Shock-From Hemodynamic Mechanisms to Clinical Applications: A State-of-the-Art Review.

Journal of cardiac failure·2026
Same author

Predictors of device-related adverse events in patients with intra-aortic ballon pump or microaxial flow pump for cardiogenic shock.

JHLT open·2026
Same author

Direct oral anticoagulants vs warfarin in Asian vs non-Asian patients with atrial fibrillation: a patient-level meta-analysis from COMBINE AF.

European heart journal·2026

Related Experiment Video

Updated: Jul 14, 2025

Induction of Right Ventricular Failure by Pulmonary Artery Constriction and Evaluation of Right Ventricular Function in Mice
09:40

Induction of Right Ventricular Failure by Pulmonary Artery Constriction and Evaluation of Right Ventricular Function in Mice

Published on: May 13, 2019

10.6K

Right Ventricular Contractility and Pulmonary Arterial Coupling After Less Invasive Left Ventricular Assist Device

George Adly1, Oliver Mithoefer1, John Elliott Epps1

  • 1From the Division of Cardiology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina.

ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|October 10, 2023
PubMed
Summary

A less invasive strategy (LIS) for left ventricular assist device implantation may preserve right ventricular (RV) contractility and improve RV-pulmonary arterial coupling compared to conventional median sternotomy (CMS). This finding suggests LIS may reduce RV failure post-implantation.

More Related Videos

Author Spotlight: Enhancing Graft Viability Assessment Through Quantitative Metrics and Innovative Reservoir Systems
08:49

Author Spotlight: Enhancing Graft Viability Assessment Through Quantitative Metrics and Innovative Reservoir Systems

Published on: August 2, 2024

771
Insertion, Maintenance, and Removal of the Percutaneous Dual Lumen Cannula Right Ventricular Assist Device
07:41

Insertion, Maintenance, and Removal of the Percutaneous Dual Lumen Cannula Right Ventricular Assist Device

Published on: July 20, 2022

1.9K

Related Experiment Videos

Last Updated: Jul 14, 2025

Induction of Right Ventricular Failure by Pulmonary Artery Constriction and Evaluation of Right Ventricular Function in Mice
09:40

Induction of Right Ventricular Failure by Pulmonary Artery Constriction and Evaluation of Right Ventricular Function in Mice

Published on: May 13, 2019

10.6K
Author Spotlight: Enhancing Graft Viability Assessment Through Quantitative Metrics and Innovative Reservoir Systems
08:49

Author Spotlight: Enhancing Graft Viability Assessment Through Quantitative Metrics and Innovative Reservoir Systems

Published on: August 2, 2024

771
Insertion, Maintenance, and Removal of the Percutaneous Dual Lumen Cannula Right Ventricular Assist Device
07:41

Insertion, Maintenance, and Removal of the Percutaneous Dual Lumen Cannula Right Ventricular Assist Device

Published on: July 20, 2022

1.9K

Area of Science:

  • Cardiovascular Surgery
  • Cardiac Physiology
  • Medical Device Technology

Background:

  • Right ventricular (RV) failure is a major complication following left ventricular assist device (LVAD) implantation.
  • Conventional median sternotomy (CMS) and less invasive strategies (LIS) are surgical approaches for LVAD implantation.
  • The impact of CMS versus LIS on RV contractility and RV-pulmonary arterial (RV-PA) coupling is not well understood.

Purpose of the Study:

  • To investigate the effect of LIS versus CMS on load-independent RV contractility and RV-PA coupling after LVAD implantation.
  • To test the hypothesis that LIS preserves RV contractility and improves RV-PA coupling compared to CMS.

Main Methods:

  • Retrospective study of patients undergoing durable centrifugal LVAD implantation with pre- and post-implantation hemodynamic assessments.
  • Determination of RV contractility (end-systolic elastance [Ees]) and RV afterload (pulmonary effective arterial elastance [Ea]) using digitized RV pressure waveforms.
  • Calculation of RV-PA coupling as the ratio Ees/Ea.

Main Results:

  • No significant differences in pre-implantation Ees, Ea, or Ees/Ea between the CMS and LIS groups.
  • Post-implantation, Ees significantly declined in the CMS group but remained stable in the LIS group.
  • RV-PA coupling (Ees/Ea) remained unchanged in the CMS group but significantly improved in the LIS group.

Conclusions:

  • LIS LVAD implantation may better preserve RV contractility compared to CMS.
  • LIS approach appears to improve RV-PA coupling post-LVAD implantation relative to CMS.
  • These findings suggest LIS may be associated with better RV functional outcomes after LVAD implantation.