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Injectable On-Demand Pulsatile Drug Delivery Hydrogels Using Alternating Magnetic Field-Triggered Polymer Glass

Scott Campbell1, Nahieli Preciado Rivera1, Somiraa Said1,2

  • 1Department of Chemical Engineering, McMaster University, 1280 Main St. W., Hamilton L8S 4L7, Ontario, Canada.

ACS Applied Materials & Interfaces
|October 10, 2023
PubMed
Summary
This summary is machine-generated.

Injectable hydrogels with magnetic nanoparticles offer precise, remote drug delivery. This minimally invasive system achieves high on/off release ratios for advanced therapeutic treatments.

Keywords:
butyl methacrylatecontrolled releaseglass transition temperatureinjectable hydrogeliron oxide nanoparticlesmethyl methacrylateon-demand drug delivery

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Drug Delivery Systems

Background:

  • Current remote-controlled drug release systems lack precision and require surgical implantation.
  • Achieving high resolution between drug release on- and off-states remains a challenge.

Purpose of the Study:

  • To develop an injectable, remotely actuated drug delivery vehicle with high on/off release resolution.
  • To overcome limitations of surgical implantation and low release control in current systems.

Main Methods:

  • Fabrication of polymeric nanoparticles (p(MMA-co-BMA)) loaded with a model drug and a glass transition temperature (Tg) near physiological temperature.
  • Co-encapsulation of drug-loaded nanoparticles with superparamagnetic iron oxide nanoparticles (SPIONs) within an injectable hydrogel matrix.
  • Remote actuation of drug release using an alternating magnetic field (AMF) for controlled heating.

Main Results:

  • The developed nanocomposite hydrogel demonstrated tunable drug release kinetics.
  • Achieved a 2.5:1 to 6:1 on/off release ratio by temperature cycling between 37 °C and 45 °C.
  • Enhanced drug release was observed upon AMF exposure, even one week post-injection, with good cytocompatibility.

Conclusions:

  • Injectable nanocomposite hydrogels offer a promising minimally invasive approach for remotely controlled drug delivery.
  • The system exhibits high on-off release resolution and sustained functionality, suitable for complex therapeutic strategies.