Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

3.2K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.2K
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

3.1K
The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
3.1K
Role of Hematopoietic Growth Factors01:28

Role of Hematopoietic Growth Factors

1.4K
Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...
1.4K
Hematopoiesis01:21

Hematopoiesis

5.3K
The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
5.3K
Overview of Hematopoiesis01:20

Overview of Hematopoiesis

4.1K
Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
4.1K
Lineage Commitment01:21

Lineage Commitment

3.0K
Commitment is the  process whereby stem cells:
3.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Leukemic stem cell subtypes determine venetoclax resistance and therapeutic vulnerabilities in AML.

Cell stem cell·2026
Same author

Lack of MDA5 delays hematopoietic aging by modulating inflammaging and proteostasis in mice.

Nature communications·2026
Same author

Somatic STAT5B<sup>N642H</sup> mutations shape variable immune landscapes resulting in heterogenous immune diseases.

The Journal of allergy and clinical immunology·2025
Same author

Oncostatin M induced by STAT5-activating oncogenes promotes disease progression in hematologic malignancies.

Signal transduction and targeted therapy·2025
Same author

The central clock drives metabolic rhythms in muscle stem cells.

Cell reports·2025
Same author

Regulation of Hematopoietic Stem Cell Dormancy and Quiescence: Insights into Regeneration and Disease.

Annual review of cell and developmental biology·2025

Related Experiment Video

Updated: Jul 14, 2025

Analysis of Hematopoietic Stem Progenitor Cell Metabolism
12:20

Analysis of Hematopoietic Stem Progenitor Cell Metabolism

Published on: November 9, 2019

6.9K

How nutrition regulates hematopoietic stem cell features.

Katharina Schönberger1, Nina Cabezas-Wallscheid1

  • 1Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.

Experimental Hematology
|October 10, 2023
PubMed
Summary

Diet significantly impacts hematopoietic stem cells (HSCs), influencing blood homeostasis. Understanding these nutritional effects may lead to interventions for aging, transplantation, and cancer therapies.

More Related Videos

Phenotypic Analysis and Isolation of Murine Hematopoietic Stem Cells and Lineage-committed Progenitors
12:03

Phenotypic Analysis and Isolation of Murine Hematopoietic Stem Cells and Lineage-committed Progenitors

Published on: July 8, 2012

18.7K
Combining Intravital Fluorescent Microscopy IVFM with Genetic Models to Study Engraftment Dynamics of Hematopoietic Cells to Bone Marrow Niches
11:06

Combining Intravital Fluorescent Microscopy IVFM with Genetic Models to Study Engraftment Dynamics of Hematopoietic Cells to Bone Marrow Niches

Published on: March 21, 2017

8.0K

Related Experiment Videos

Last Updated: Jul 14, 2025

Analysis of Hematopoietic Stem Progenitor Cell Metabolism
12:20

Analysis of Hematopoietic Stem Progenitor Cell Metabolism

Published on: November 9, 2019

6.9K
Phenotypic Analysis and Isolation of Murine Hematopoietic Stem Cells and Lineage-committed Progenitors
12:03

Phenotypic Analysis and Isolation of Murine Hematopoietic Stem Cells and Lineage-committed Progenitors

Published on: July 8, 2012

18.7K
Combining Intravital Fluorescent Microscopy IVFM with Genetic Models to Study Engraftment Dynamics of Hematopoietic Cells to Bone Marrow Niches
11:06

Combining Intravital Fluorescent Microscopy IVFM with Genetic Models to Study Engraftment Dynamics of Hematopoietic Cells to Bone Marrow Niches

Published on: March 21, 2017

8.0K

Area of Science:

  • Hematology
  • Metabolism
  • Stem Cell Biology

Background:

  • Dietary choices profoundly affect cellular functions throughout the body.
  • Emerging research links diet-derived metabolites to hematopoietic stem cell (HSC) metabolism and function.
  • Maintaining HSC metabolic activity is vital for blood homeostasis and preventing hematologic disorders.

Purpose of the Study:

  • To review current knowledge on diet's impact on stemness features.
  • To highlight mechanisms of dietary component modulation of HSC metabolic and transcriptional programs.
  • To explore the potential of nutritional interventions in aging, transplantation, and cancer therapy.

Main Methods:

  • Literature review of scientific studies on diet and HSCs.
  • Analysis of established mechanisms linking dietary components to HSC function.
  • Synthesis of current understanding of nutrition's role in stem cell biology.

Main Results:

  • Dietary metabolites actively modulate HSC metabolism and function.
  • Specific dietary components influence metabolic and transcriptional pathways in adult HSCs.
  • Nutrition plays a key role in maintaining HSC fitness and blood homeostasis.

Conclusions:

  • Understanding diet-HSC interactions is crucial for maintaining stem cell health.
  • Targeted dietary interventions show promise for decelerating aging.
  • Nutritional strategies may enhance transplantation and cancer therapies.