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Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness
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Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness

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Carotid artery stiffness and risk of vascular events and mortality: the REGICOR study

Roberto Elosua1, Andrea Toloba2, Roman Arnold3

  • 1Institut Hospital del Mar d'Investigacions Mèdiques (IMIM), Barcelona, Spain; Centro de Investigación en Red de Enfermedades Cardiovasculares (CIBERCV), Spain; Facultat de Medicina, Universitat de Vic-Universitat Central de Catalunya, Vic, Barcelona, Spain.

Revista Espanola De Cardiologia (English Ed.)
|October 10, 2023
PubMed

Insights

Carotid stiffness measures like pulse wave velocity are linked to cerebrovascular disease risk. However, these arterial stiffness indices do not improve existing risk prediction models for vascular events.

Area of Science:

  • Cardiovascular Medicine
  • Biomedical Engineering
  • Epidemiology

Background:

  • Arterial stiffness is an indicator of cardiovascular health.
  • Assessing carotid artery stiffness may offer insights into vascular disease prediction.

Purpose of the Study:

  • To examine the relationship between carotid arterial stiffness and vascular outcomes, including overall mortality.
  • To determine if carotid stiffness indices enhance the predictive ability of established risk functions.

Main Methods:

  • A population-based cohort study of 6468 individuals with a median follow-up of 6.5 years.
  • Six carotid artery stiffness indices were measured: strain, stiffness, Peterson elasticity coefficient, compliance coefficient, distensibility coefficient, and pulse wave velocity (PWV).
  • Incident cardiovascular events and mortality were recorded.

Main Results:

  • Carotid stiffness, Peterson elasticity coefficient, and PWV showed a linear association with increased cerebrovascular disease risk.
  • Carotid strain demonstrated a nonlinear, U-shaped association with ischemic heart disease risk.
  • The inclusion of carotid stiffness indices did not significantly improve the predictive capacity of existing risk prediction models.

Conclusions:

  • Specific carotid arterial stiffness measures, including PWV, are associated with cerebrovascular disease risk.
  • Carotid strain has a complex, nonlinear relationship with ischemic heart disease risk.
  • Current carotid stiffness indices do not add significant predictive value to established cardiovascular risk functions.
Abstract

Keywords:
Capacidad predictivaCarotid stiffnessCerebrovascular diseaseEnfermedad cerebrovascularEnfermedad coronariaIschemic heart diseasePredictive capacityRigidez carotídea

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