Hemoperfusion in reduced-time programmes for chronic uremia. Long-term results

Area of Science:

• Nephrology
• Biomedical Engineering

Background:

• Chronic uremic patients require regular dialysis, which is time-consuming.
• Reducing dialysis treatment time is crucial for improving patient quality of life and resource management.

Purpose of the Study:

• To evaluate the clinical efficacy of charcoal hemoperfusion in reducing weekly dialysis time for chronic uremic patients.
• To compare two different treatment programs utilizing combined hemodialysis and hemoperfusion.

Main Methods:

• An 8-year clinical experience with two treatment programs (A and B) involving combined hemodialysis and hemoperfusion.
• Programme A: Reduced 3 standard dialysis sessions to 2 combined sessions per week.
• Programme B: Modified 3 weekly sessions, with 2 combined and 1 conventional dialysis.

Main Results:

• Programme A achieved a 33% net weekly reduction in treatment time.
• Programme B achieved a 25% net weekly reduction in treatment time.
• Efficacy was assessed using clinical, hematochemical, nutritional, and instrumental parameters.

Conclusions:

• Charcoal hemoperfusion can significantly reduce weekly dialysis time in chronic uremic patients.
• Both evaluated programs demonstrated feasibility and time-saving benefits.
• Further evaluation of clinical outcomes is warranted to fully assess the impact of reduced treatment duration.