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Exploring oncogenes for renal clear cell carcinoma based on G protein-coupled receptor-associated genes

Chengcun Zhu1, Zhou Sun2, Jie Wang2,3

  • 1Department of Urology, The First People's Hospital of Jiangxia District, Wuhan, 430200, Hubei, China.

Discover Oncology
|October 10, 2023
PubMed

Insights

This study explores G protein-coupled receptors (GPCRs) in renal clear cell carcinoma, identifying their role in prognosis and developing a predictive disease model for targeted therapies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genomics

Background:

  • G protein-coupled receptors (GPCRs) are crucial cell membrane regulators of biological processes.
  • The prognostic significance of GPCRs in renal clear cell carcinoma (ccRCC) remains largely unexplored.

Purpose of the Study:

  • To investigate the role of GPCR-related genes in ccRCC diagnosis and prognosis.
  • To establish a predictive disease model for personalized therapeutic strategies in ccRCC patients.

Main Methods:

  • Utilized TCGA and GEO databases for transcriptome and clinical data analysis.
  • Performed GSEA, WGCNA, single-cell RNA sequencing, and mutation analyses.
  • Validated findings through cellular experiments.

Main Results:

  • Identified GPCR-related genes with potential diagnostic and prognostic value in ccRCC.
  • Developed a novel disease model for ccRCC stratification.
  • Demonstrated the reliability of findings via cellular experiments.

Conclusions:

  • GPCR-related genes play a significant role in ccRCC progression and patient outcomes.
  • The established disease model offers a promising tool for targeted therapy selection in ccRCC.
  • Further research into GPCRs could lead to improved ccRCC management.
Keywords:
Clear cell renal cell carcinomaG protein-coupled receptorsSingle cell RNA sequencingSurvival analysisTCGATranscriptome profilingTumor microenvironment

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