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Related Experiment Video

Updated: Jul 14, 2025

Occlusion of the Great and Small Saphenous Vein Using Copolymeric Glue Based on N-Butyl Cyanoacrylate and Methacryloxy Sulfolane

Occlusion of the Great and Small Saphenous Vein Using Copolymeric Glue Based on N-Butyl Cyanoacrylate and Methacryloxy Sulfolane

Published on: December 9, 2022

Cyanoacrylate glue as part of a new bundle to decrease neonatal PICC-related complications.

Fiammetta Piersigilli¹, Giulia Iacona², Sarah Yazami³

¹Division of Neonatology, Cliniques Universitaires Saint Luc, Université Catholique de Louvain, Avenue Hippocrate 10, 1200, Brussels, Brussels, Belgium. Fiammetta.piersigilli@saintluc.uclouvain.be.

European Journal of Pediatrics

|October 10, 2023

Summary

Implementing a new central line bundle significantly reduced bloodstream infections and dislodgments in neonatal intensive care units. This evidence-based approach improved patient safety without causing glue-related complications.

Keywords:

CLABSI Central venous catheter Glue NICU Neonate PICC Securement

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Published on: June 13, 2025

Area of Science:

Neonatal care
Medical device securement
Infection control

Background:

Stable vascular access is critical for neonates in the NICU.
PICC securement issues can lead to serious consequences and device failure.
Tissue adhesive securement is proven safe and effective for neonatal catheters.

Purpose of the Study:

To evaluate the impact of a central line dressing and maintenance bundle on catheter-related mechanical complications.
To assess the effectiveness of a new PICC bundle in a level-III NICU.
To reduce catheter-related mechanical complications and infections.

Main Methods:

A quasi-experimental quality improvement project was conducted.
A new PICC bundle including glue, a sutureless device (Griplock®), and transparent dressing was implemented.
Complication rates were compared before and after bundle implementation.

Main Results:

The new bundle significantly decreased central line-associated bloodstream infections (CLABSI) (p<0.001).
Mechanical complications and dislocations were significantly reduced (p<0.0001).
The average catheter dwell time increased significantly (p<0.05), with no observed glue-related complications.

Conclusions:

The new neonatal PICC securement bundle effectively reduced CLABSI and dislodgment rates.
No complications were associated with the use of glue in the neonatal population.
Continuous implementation of evidence-based central line bundles is crucial for improving NICU patient safety and quality improvement.