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Association of glycemic control with hypertension in patients with diabetes: a population-based longitudinal study

Shengliang Chen1, Yi Zhu1, Sihui Jin1

  • 1Department of Health Policy and Management, School of Public Health, Sun Yat-sen University, 74, Zhongshan 2nd Road, Guangzhou, 510030, Guangdong, P. R. China.

BMC Cardiovascular Disorders
|October 10, 2023
PubMed

Insights

Poor glycemic control in individuals with diabetes significantly increases hypertension risk. This association is stronger in those with lower education and depressive symptoms, highlighting the need for comprehensive management.

Area of Science:

  • Endocrinology
  • Cardiovascular Health
  • Public Health

Background:

  • Diabetes mellitus is a known risk factor for hypertension.
  • The specific impact of glycemic control on hypertension development in diabetic populations requires further investigation.

Purpose of the Study:

  • To investigate the association between glycemic control and the incidence of hypertension among individuals with diabetes.
  • To explore potential moderating factors such as educational attainment and depressive symptoms.

Main Methods:

  • Utilized data from the China Health and Retirement Longitudinal Study (CHARLS) from 2011-2018.
  • Categorized participants based on HbA1c levels (adequate <7% vs. inadequate ≥7%) and physician-diagnosed hypertension.
  • Employed Cox proportional hazards regression models to analyze the risk of developing hypertension.

Main Results:

  • Inadequate glycemic control was associated with a 1.54-fold increased hazard of hypertension (95% CI, 1.07-2.21) compared to adequate control.
  • The association between glycemic control and hypertension risk was significantly modified by educational attainment and the presence of depressive symptoms (P < 0.05).

Conclusions:

  • Insufficient glycemic control is a significant risk factor for hypertension in diabetic individuals.
  • Educational background and mental health status (depressive symptoms) are important factors influencing this association.
  • Emphasizes the importance of rigorous glycemic monitoring and holistic patient assessment in diabetes management.
Abstract

Keywords:
Diabetes mellitusGlycemic ControlHypertension

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