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Related Concept Videos

Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

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Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
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Related Experiment Video

Updated: Jul 14, 2025

Isolating Bronchial Epithelial Cells from Resected Lung Tissue for Biobanking and Establishing Well-Differentiated Air-Liquid Interface Cultures
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Isolating Bronchial Epithelial Cells from Resected Lung Tissue for Biobanking and Establishing Well-Differentiated Air-Liquid Interface Cultures

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Bronchial epithelial gene expression and interstitial lung abnormalities.

Aravind A Menon1, Minyi Lee2, Xu Ke2

  • 1Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, MA, 02115, USA.

Respiratory Research
|October 11, 2023
PubMed
Summary
This summary is machine-generated.

Interstitial lung abnormalities (ILA) with a usual interstitial pneumonia (UIP) pattern show differential gene expression, particularly in inflammatory pathways. This finding may aid in developing biomarkers for progressive pulmonary fibrosis.

Area of Science:

  • Pulmonary Medicine
  • Genomics
  • Fibrotic Lung Disease

Background:

Keywords:
Gene expressionILAInterstitial lung abnormalitiesInterstitial lung diseaseLung fibrosis

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  • Interstitial lung abnormalities (ILA) can indicate early fibrotic changes and predict progressive fibrotic lung disease.
  • Fibrotic ILA is linked to increased mortality and accelerated lung function decline.
  • Identifying differential gene expression in fibrotic ILA may reveal biomarkers for early detection and therapeutic targets.