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Non-nutritive Sweeteners: Weight Loss or Weight Gain?
Sarah Khalil1, Yara Haikal1, Antoine Aoun1,2,3,4
1Department of Nursing and Health Sciences, Notre Dame University-Louaize, 72 Zouk Mikael, Zouk Mosbeh, Lebanon.
Endocrine, Metabolic & Immune Disorders Drug Targets
|October 11, 2023
Summary
Non-nutritive sweeteners (NNS) consumption is increasing, but their impact on human weight remains inconclusive. Current evidence suggests NNS effects on weight are weak and influenced by other behaviors.
Area of Science:
- Nutrition Science
- Metabolic Health
- Food Science
Background:
- Non-nutritive sweeteners (NNS) are widely consumed globally.
- The health effects and weight impact of chronic NNS use are debated and not fully understood.
- Existing research presents conflicting evidence on NNS and weight control.
Purpose of the Study:
- To review the current scientific evidence on the biological role of NNS.
- To analyze the effects of NNS on human weight.
- To discuss the mechanisms by which NNS may influence weight management.
Main Methods:
- Systematic review of published literature.
- Analysis of studies investigating NNS effects on sweet taste receptors, cognition, and metabolic functions.
- Examination of NNS impact on the gut microbiota and adiposity.
Main Results:
- Conflicting evidence exists regarding the definitive impact of NNS on human weight.
- Mechanisms discussed include effects on sweet taste, endocrine function, and gut microbiota.
- Evidence against NNS use in weight management is currently considered weak.
Conclusions:
- The overall impact of NNS on weight is not definitively established.
- Further research is needed to clarify the role of NNS in weight regulation.
- Behavioral patterns significantly influence the ultimate effect of NNS on body weight.
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