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Changes in vascular access profile for pediatric hemodialysis patients over time: A registry-based study from
Ramon Roca-Tey1, Gema Ariceta2,3, Héctor Ríos2
1Department of Nephrology, Hospital Universitari Mollet, Fundació Sanitària Mollet, Mollet del Vallès, Barcelona, Spain.
Insights
Vascular access choices for pediatric hemodialysis patients have shifted, with fewer starting dialysis and more receiving kidney transplants. The increasing kidney transplant rate significantly influences vascular access selection in Catalonia.
Area of Science:
- Nephrology
- Pediatric Nephrology
- Vascular Access
Background:
- Vascular access (VA) selection criteria for pediatric hemodialysis (HD) have evolved towards a patient-centered approach.
- This study examines VA types used in pediatric end-stage kidney disease (ESKD) patients on HD in Catalonia.
Purpose of the Study:
- To analyze trends in vascular access utilization for pediatric patients with end-stage kidney disease (ESKD) undergoing hemodialysis (HD).
- To investigate the impact of changing treatment paradigms, such as increased kidney transplantation, on VA selection in pediatric HD patients.
Main Methods:
- Retrospective analysis of the Catalan Renal Registry data for pediatric patients (<18 years) from 1997 to 2018.
- Examined kidney replacement therapy (KRT) modalities and vascular access types (fistula, catheter) for incident and prevalent ESKD patients.
Main Results:
- The proportion of children starting KRT with HD decreased, while preemptive kidney transplantation (KT) increased significantly.
- Use of arteriovenous fistula (AVF) for initiating HD in children declined, with a rise in tunneled catheter use.
- The prevalence of children on HD decreased, with a corresponding increase in functioning kidney grafts; KT rates rose substantially.
Conclusions:
- The increasing kidney transplantation rate is a key factor influencing vascular access choices in pediatric HD patients.
- Treatment strategies are shifting towards transplantation, impacting the types of vascular access required for pediatric end-stage kidney disease management.
Background:
The criteria for vascular access (VA) selection in pediatric hemodialysis (HD) population has changed over time until the current patient-centered approach using the individualized Life-Plan. We analyzed the type of VA used by incident and prevalent end-stage kidney disease (ESKD) pediatric patients (pts) treated with HD in Catalonia.
Method:
Data from the Catalan Renal Registry of ESKD pts under 18 years of age undergoing kidney replacement therapy (KRT) were examined for a 22-year period (1997-2018).
Results:
ESKD children starting KRT through HD decreased progressively from 55.6% (1997-2001) to 38.2% (2012-2018) and, conversely, there was an increase in pts starting KRT by preemptive kidney transplantation (KT) from 28.9% to 42.6% between the same periods (for both comparisons, p = 0.007). Most ESKD pts started HD by fistula (AVF) from 1997 to 2001 (56.5%) but this percentage decreased over time and no AVFs were used to start HD in children from 2012 to 2018. Likewise, the percentage of children starting HD by tunneled catheter increased progressively from 8.7% to 72.2% between the same periods (for both comparisons, p < 0.001). Regarding prevalent ESKD pts, children on HD decreased from 34.9% in 1997 to 4.7% in 2018 and, conversely, pts with a functioning kidney graft increased from 62.8% to 92.4% during the same periods (for both comparisons, p < 0.001). There was a progressive decrease in the percentage of children dialyzed by AVF from 100% in 1997 to 0% in 2018 (p < 0.001). The KT rate increased from 5.4 per million population (pmp) in 1997 to 17.1 pmp in 2018 (p = 0.007). The median time on HD prior to the first KT progressively decreased to 6.6 months (2014-2018).
Conclusion:
The high KT rate was a determining factor in choosing the VA type in the incident and prevalent pediatric population treated with HD in Catalonia.
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