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Benefits of using polymeric nanoparticles in breast cancer treatment: a systematic review
Joabe Lima Araújo1, Julia Augusto Vieira1, Mayla Dos Santos Silva2
1Department of Genetics and Morphology, Institute of Biological Sciences, Darcy Ribeiro University Campus, University of Brasília, Brasília-DF, 70910-900 Brazil.
Abstract:
Breast cancer comprises approximately 20% of all malignant neoplasm cases globally. Due to the limitations associated with conventional therapeutic approaches, extensive investigations have been undertaken to develop novel treatments that exhibit enhanced specificity and minimized adverse effects. Consequently, the application of polymeric nanoformulations for targeted drug delivery has gained significant attention within the biomedical field. Therefore, the primary objective of this study was to explore the inherent advantages and efficacy of employing polymeric nanoformulations for drug delivery in breast cancer treatment, as compared to traditional therapies. A comprehensive literature search was conducted across prominent databases including PubMed/MEDLINE, Embase, and Scopus, utilizing specific search strings. This meticulous approach yielded a total of 12 relevant articles for in-depth analysis and discussion. The findings from the selected studies underscore the effectiveness of employing polymeric nanoparticles as a drug delivery strategy, showcasing noteworthy improvements in cellular uptake and sustained intracellular retention of encapsulated therapeutic agents. Additionally, these nanoformulations exhibited superior efficacy, safety, and drug delivery capabilities. The utilization of polymeric nanoparticles in drug delivery has demonstrated a substantial enhancement in treatment efficacy, with the ability to achieve higher concentrations of active ingredients within tumor tissues, augment cellular uptake and drug concentrations, and sustain intracellular retention. Consequently, this innovative approach prolongs drug release in lower quantities, ultimately contributing to improved treatment outcomes.
Insights
Polymeric nanoparticles enhance breast cancer treatment by improving drug delivery and cellular uptake. This targeted approach offers superior efficacy and safety compared to traditional therapies.
Area of Science:
- Biomedical Engineering
- Oncology
- Nanotechnology
Background:
- Breast cancer is a leading global malignancy, necessitating advanced therapeutic strategies.
- Conventional treatments face limitations in specificity and adverse effects.
- Polymeric nanoformulations are emerging as promising tools for targeted drug delivery.
Purpose of the Study:
- To evaluate the advantages and efficacy of polymeric nanoformulations for breast cancer drug delivery.
- To compare nanoformulation-based delivery with traditional therapeutic methods.
Main Methods:
- A systematic literature search was performed across PubMed/MEDLINE, Embase, and Scopus.
- 12 relevant studies were selected for analysis.
Main Results:
- Polymeric nanoparticles significantly improve cellular uptake and intracellular drug retention.
- Nanoformulations demonstrate enhanced efficacy, safety, and drug delivery capabilities.
- Higher concentrations of active ingredients are achieved within tumor tissues.
Conclusions:
- Polymeric nanoparticles offer a superior drug delivery strategy for breast cancer treatment.
- This approach leads to improved therapeutic outcomes through sustained drug release and enhanced efficacy.
