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Conjunctival Involvement in Infants as an Unusual Symptom of Omicron XBB.1.16 Driven Surge

Vipin M Vashishtha1, Puneet Kumar2

  • 1Department of Pediatrics, Mangla Hospital and Research Center, Shakti Chowk, Bijnor, Uttar Pradesh. vipinipsita@gmail.com.

Indian Pediatrics
|October 11, 2023
PubMed

Insights

Young infants showed higher SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2) positivity during the XBB.1.16 variant surge. Non-purulent conjunctivitis was common in infants, with all recovering with outpatient care.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Virology

Background:

  • The study investigated clinical features of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infections in children during the XBB.1.16 variant surge in India (April 2023).
  • Focus was placed on comparing infection rates and symptom presentation between young infants and older children.

Discussion:

  • A significantly higher SARS-CoV-2 positivity rate was observed in young infants (37.4%) compared to older children (13.3%).
  • Respiratory symptoms predominated in infected children.
  • A notable finding was the occurrence of non-purulent conjunctivitis in 36.8% of SARS-CoV-2 positive infants.

Key Insights:

  • The XBB.1.16 variant disproportionately affected young infants, indicating potential age-specific susceptibility.
  • Non-purulent conjunctivitis emerged as a significant clinical manifestation in SARS-CoV-2 infected infants during this surge.
  • All affected children, including infants with conjunctivitis, experienced favorable outcomes with symptomatic outpatient treatment.

Outlook:

  • Further research into age-specific immune responses to SARS-CoV-2 variants like XBB.1.16 is warranted.
  • Understanding the link between respiratory infections and conjunctivitis in infants may inform clinical management and public health strategies.
  • Continued surveillance of emerging SARS-CoV-2 variants and their pediatric impact is crucial.

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