Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Multiple Sclerosis l: Introduction

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Correction: Stability in Cognition and Employment in People with Relapsing Multiple Sclerosis Treated with Cladribine Tablets: Two‑year Phase IV CLARIFY‑MS Study.

Neurology and therapy·2026

Same author

Normative T<sub>1</sub> and T<sub>2</sub> Brain Atlases Across the Adult Lifespan in a Chinese Cohort: Multicenter Quantitative MRI Benchmarks for Ageing and Neurodegenerative Research.

Human brain mapping·2026

Same author

Exploring an integrated group psychotherapy-exercise program for multiple sclerosis: a non-randomized pilot study.

Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·2026

Same author

Adherence to risk minimization measures for alemtuzumab use in multiple sclerosis: a drug utilization study in four European countries.

Therapeutic advances in neurological disorders·2026

Same author

Healthy knee cartilage T2 mapping assessed with GRAPPATINI and multi-echo spin-echo (MESE) at 3T: regional values, longitudinal repeatability and method agreement.

Quantitative imaging in medicine and surgery·2026

Same author

Reducing Noise Induced by Cardiac Pulsatility in Brain Maps of R<sub>2</sub>* and Magnetic Susceptibility Using Tailored k-space Sampling.

NMR in biomedicine·2026

Search research articles

Related Experiment Video

Updated: Jun 9, 2026

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool

Published on: June 30, 2014

Tract-wise microstructural analysis informs on current and future disability in early multiple sclerosis.

Veronica Ravano^1,2,3, Gian Franco Piredda^4,5,6, Jan Krasensky⁷

¹Advanced Clinical Imaging Technology, Siemens Healthineers International AG, Lausanne, Switzerland. veronica.ravano@epfl.ch.

Journal of Neurology

|October 11, 2023

Summary

This summary is machine-generated.

Quantitative MRI reveals that microstructural changes in white matter (WM) tracts predict future disability in early multiple sclerosis (MS) patients, offering a new way to monitor disease progression.

Keywords:

Demyelinating diseases Magnetic resonance imaging Multiple sclerosis Relaxometry White matter

More Related Videos

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Published on: February 19, 2021

Related Experiment Videos

Last Updated: Jun 9, 2026

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool

Published on: June 30, 2014

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Magnetic Resonance Imaging of Multiple Sclerosis at 7.0 Tesla

Published on: February 19, 2021

Area of Science:

Neuroimaging
Neurology
Biomarkers

Background:

Microstructural characterization in multiple sclerosis (MS) better predicts disability than conventional imaging biomarkers.
Quantitative MRI effectively detects microstructural changes in brain lesions and normal-appearing tissue.
The impact of microstructural alterations along specific neuronal pathways remains underexplored.

Purpose of the Study:

To investigate the extent and location of quantitative MRI-detected tissue changes along white matter (WM) tracts.
To correlate these microstructural alterations with cross-sectional disability and future disability progression in MS patients.

Main Methods:

Voxel-wise T1 alterations were quantified in 99 MS patients compared to normative data.
WM tract metrics for tissue alterations (lesions and normal-appearing WM) were extracted.
Correlations were performed between WM tract metrics and cross-sectional/evolving disability.

Main Results:

In early MS, T1 alterations in normal-appearing WM correlated better with disability evolution than cross-sectional disability.
Lesions in supratentorial tracts associated more with current disability; infratentorial alterations predicted future disability.
In progressive MS, all WM pathways contributed similarly to disability, with poor correlations for disability evolution.

Conclusions:

Microstructural changes in specific WM pathways predict future disability in early MS, supporting tract-wise analysis for disease monitoring.
The technique provides WM tract-specific microstructural insights within clinically feasible scan times, without requiring advanced diffusion imaging.