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Related Concept Videos

Development of Antibiotic Resistance01:30

Development of Antibiotic Resistance

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Antibiotic resistance is a major public health concern that arises when bacteria evolve mechanisms to withstand the effects of antibiotic treatments. This resistance can be intrinsic, acquired through genetic mutations, or transferred between bacteria via horizontal gene transfer. The development of antibiotic resistance poses significant challenges in treating bacterial infections and necessitates ongoing research to develop new therapeutic strategies.Intrinsic resistance occurs when bacterial...
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Combined Effects of Drugs: Synergism01:27

Combined Effects of Drugs: Synergism

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Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
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Drug Discovery: Overview01:26

Drug Discovery: Overview

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Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
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Gene Regulation in Microbial Communities: Quorum Sensing01:28

Gene Regulation in Microbial Communities: Quorum Sensing

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Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
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Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

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Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
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Updated: Jul 13, 2025

Antibiotic Dereplication Using the Antibiotic Resistance Platform
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Small-Molecule Antibiotic Drug Development: Need and Challenges.

Megan Bergkessel1, Barbara Forte2, Ian H Gilbert2

  • 1Division of Molecular Microbiology, School of Life Sciences, University of Dundee, Dundee DD1 5EH, U.K.

ACS Infectious Diseases
|October 11, 2023
PubMed
Summary
This summary is machine-generated.

The urgent need for new antibiotics is driven by rising antimicrobial resistance and persistent deaths from drug-sensitive infections. Small-molecule antibiotics are crucial, especially in low-income countries, despite development challenges.

Keywords:
antibiotic drug discoveryantibiotic toleranceantimicrobial resistancesmall-molecule antibiotic

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Area of Science:

  • Microbiology
  • Infectious Diseases
  • Drug Discovery

Background:

  • Antimicrobial resistance (AMR) is a growing global threat, exacerbated by pathogen evolution and antibiotic use.
  • Drug-resistant and opportunistic bacterial infections pose significant risks, particularly to vulnerable populations.
  • Global health challenges like aging populations and resource limitations intensify the need for effective treatments.

Purpose of the Study:

  • To address the urgent need for novel antibiotics.
  • To highlight challenges and potential solutions in small-molecule antibiotic development.
  • To emphasize the importance of small-molecule antibiotics in global health, especially in resource-limited settings.

Main Methods:

  • Review of historical antibiotic treatment context.
  • Analysis of scientific and market-related challenges in small-molecule antibiotic discovery.
  • Exploration of potential solutions and strategies for future development.

Main Results:

  • Antimicrobial resistance and opportunistic infections are increasing, leading to significant mortality.
  • Small-molecule antibiotics offer advantages for managing infections in resource-limited settings.
  • Current small-molecule antibiotic discovery faces scientific and market-related hurdles.

Conclusions:

  • Continued investment in small-molecule antibiotic development is essential.
  • Addressing challenges in antibiotic development is critical for combating bacterial infections globally.
  • Integrated approaches combining multiple strategies are likely necessary for future success.