Related Experiment Video
Updated: Jul 13, 2025

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
Published on: June 13, 2021
Socioeconomic resources moderate the relationship between maternal prenatal obsessive-compulsive symptoms and infant
Jason M Gibbs1, Nicki L Aubuchon-Endsley1
1Idaho State University, Pocatello, ID, USA.
Insights
Maternal prenatal obsessive-compulsive symptoms may impact infant negative affectivity, especially with fewer socioeconomic resources. However, this link was not significant when using observed infant behaviors.
Area of Science:
- Psychiatry
- Developmental Psychology
- Perinatal Mental Health
Background:
- Perinatal maternal mental health issues like depression and anxiety are linked to adverse infant outcomes.
- The impact of maternal obsessive-compulsive symptomatology during the perinatal period on infant outcomes remains understudied.
- Socioeconomic factors may influence the relationship between maternal mental health and infant development.
Purpose of the Study:
- To examine the effects of prenatal and postnatal maternal obsessive-compulsive symptoms on infant behavioral reactivity at 6 months.
- To assess if these effects persist beyond the influence of maternal depressive symptoms.
- To investigate the moderating role of socioeconomic resources in these associations.
Main Methods:
- Longitudinal study of 125 pregnant women from a Health Professional Shortage Area in the Midwest US.
- Maternal questionnaires assessing obsessive-compulsive and depressive symptoms at 34 weeks gestation and 6 months postpartum.
- Infant behavioral reactivity assessed at 6 months via behavioral observation and maternal report.
Main Results:
- Maternal postnatal depressive symptoms were associated with higher infant negative affectivity reported by mothers.
- Socioeconomic resources moderated the association between maternal prenatal obsessive-compulsive symptoms and mother-reported infant negative affectivity.
- No significant associations were found when infant reactivity was measured by behavioral observation.
Conclusions:
- Maternal obsessive-compulsive symptoms during pregnancy may be linked to infant negative affectivity, particularly in contexts of limited socioeconomic resources, when relying on maternal reports.
- The findings highlight the importance of considering both maternal mental health and socioeconomic context in infant development.
- Discrepancies between maternal report and observational data underscore the complexity of measuring infant behavioral reactivity.
Abstract:
Perinatal maternal depression, anxiety, and stress are associated with poor infant outcomes. However, no known study has investigated the effects of perinatal maternal obsessive-compulsive symptomatology on infant outcomes while considering important situational factors such as socioeconomic resources. Therefore, we investigated the effects of prenatal and postnatal obsessive-compulsive symptomatology on infant behavioral reactivity, beyond the effects of postnatal depressive symptomatology, at 6 months of age. It was expected that socioeconomic resources would moderate this relationship. We recruited 125 pregnant women from a Health Professional Shortage Area for mental health and primary care in the Midwest United States and interviewed them at approximately 34 weeks gestation and again at 6 months postnatally. They were administered questionnaires at both time points measuring obsessive-compulsive and depressive symptoms. Infant behavioral reactivity was gathered during 6-month follow-up through behavioral observation coding and maternal-report modalities. Maternal-reported infant negative affectivity at 6 months was related to greater severity of maternal postnatal depressive symptomatology, and socioeconomic resources moderated the relationship between maternal prenatal obsessive-compulsive symptoms and maternal-reported infant negative affectivity. However, neither of these relations was statistically significant when infant reactivity was quantified using behavioral observations.
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