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Solid-state vibrational circular dichroism: Methodology and application for amphetamine derivatives.

K Dobšíková1, T Taušová1, P Fagan1

  • 1Department of Analytical Chemistry, University of Chemistry and Technology, Technická 5, Prague 6 166 28, Czech Republic.

Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
|October 11, 2023
PubMed
Summary
This summary is machine-generated.

Solid-state vibrational circular dichroism (VCD) spectroscopy effectively distinguishes between (S)- and (R)-amphetamine enantiomers. This cost-effective method offers potential for pharmaceutical and forensic analysis of seized substances.

Keywords:
Amphetamine derivativesChiroptical spectroscopyMethodologySolid-state vibrational circular dichroism

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Area of Science:

  • Analytical Chemistry
  • Spectroscopy
  • Forensic Science

Background:

  • Amphetamine derivatives are frequently seized illicit substances globally.
  • Enantiomeric discrimination is crucial for forensic and pharmaceutical analysis.
  • Solid-state spectroscopy offers advantages for analyzing crystalline compounds.

Purpose of the Study:

  • To develop a reliable method for solid-state vibrational circular dichroism (VCD) spectroscopy.
  • To apply solid-state VCD for differentiating between enantiomers of amphetamine and its derivatives.
  • To assess the potential of VCD in pharmaceutical and forensic applications.

Main Methods:

  • Development of a universal experimental approach for solid-state VCD.
  • Sample preparation using pellets of camphor and crystalline matrix powder.
  • Optimization of pellet thickness, diameter, and sample rotation speed for VCD measurements.

Main Results:

  • Achieved reliable and reproducible solid-state VCD spectra.
  • Successfully discriminated between (S)- and (R)-enantiomers of amphetamine, methamphetamine, and MDMA.
  • Demonstrated high-quality spectra with excellent signal-to-noise ratios.

Conclusions:

  • Solid-state VCD spectroscopy is a cost-effective and user-friendly technique.
  • VCD is suitable for analyzing conformational changes and molecular packing in solids.
  • The method shows significant potential for pharmaceutical quality control and forensic analysis of seized drugs.