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Related Concept Videos

Increased Body Temperature01:25

Increased Body Temperature

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A body temperature above  38°C  (100.4 °F) is known as fever or pyrexia, and a person with fever is termed 'febrile.' Typically, the hypothalamus, a part of the brain that acts as the body's thermostat, regulates body temperature through a thermoregulatory setpoint. It receives signals from cold and warm thermal receptors throughout the body and adjusts the body's temperature accordingly. Fever occurs when this hypothalamic setpoint is altered, usually in...
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Homeostatic Imbalances in Body Temperature01:19

Homeostatic Imbalances in Body Temperature

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Hyperthermia occurs when the body's temperature becomes unusually high, often due to heat exposure, intense physical activity, or certain illnesses. This condition can create a dangerous cycle where elevated body temperature increases the metabolic rate, generating more heat and potentially leading to organ failure and brain damage. A severe form of hyperthermia, called heat stroke, can raise body temperature to life-threatening levels. Fever, on the other hand, is a controlled form of...
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Desensitization and Tachyphylaxis01:20

Desensitization and Tachyphylaxis

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Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.
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Thermosensation01:43

Thermosensation

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Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
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Factors Affecting Body Temperature01:28

Factors Affecting Body Temperature

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As a nurse, it is vital to understand the factors affecting body temperature to monitor variations and effectively evaluate deviations from regular.
Factors may  include:
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Related Experiment Video

Updated: Jul 13, 2025

Author Spotlight: Computing the Effects of a Local Radiofrequency Hyperthermia Intervention on Tumor Biomechanics
10:23

Author Spotlight: Computing the Effects of a Local Radiofrequency Hyperthermia Intervention on Tumor Biomechanics

Published on: December 1, 2023

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Radiosensitization by Hyperthermia Critically Depends on the Time Interval.

Xionge Mei1, H Petra Kok2, Hans M Rodermond1

  • 1Department of Radiation Oncology, University of Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands; Center for Experimental and Molecular Medicine (CEMM), Laboratory for Experimental Oncology and Radiobiology (LEXOR), Amsterdam, The Netherlands; Cancer Biology and Immunology, Cancer Center Amsterdam, Amsterdam, The Netherlands.

International Journal of Radiation Oncology, Biology, Physics
|October 11, 2023
PubMed
Summary
This summary is machine-generated.

Shortening the interval between hyperthermia and radiation therapy significantly improves outcomes for locally advanced cervical cancer (LACC) patients. The sequence of treatments does not impact results, making timing the key factor for enhanced radiosensitization.

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Area of Science:

  • Oncology
  • Radiation Oncology
  • Cancer Biology

Background:

  • Hyperthermia enhances radiation therapy efficacy for locally advanced cervical cancer (LACC).
  • Optimal timing and sequence of hyperthermia and radiation therapy remain under investigation for LACC treatment.

Purpose of the Study:

  • To determine the impact of the interval and sequence of hyperthermia and radiation therapy on LACC treatment outcomes.
  • To evaluate hyperthermic radiosensitization in preclinical models and clinical data.

Main Methods:

  • In vitro studies using cervical cancer cell lines and patient-derived organoids.
  • In vivo studies using SiHa cervical cancer xenografts in mice.
  • Retrospective analysis of 58 LACC patients treated with thermoradiotherapy.

Main Results:

  • Shortening the interval between hyperthermia and radiation therapy increased radiosensitization 2-8 fold, leading to more DNA damage and apoptosis.
  • Reduced cell survival by 10-100 fold, delayed tumor growth in mice, and improved 5-year survival rates in LACC patients.
  • The sequence of hyperthermia and radiation therapy did not significantly affect treatment outcomes.

Conclusions:

  • A shorter interval between hyperthermia and radiation therapy significantly improves treatment outcomes for LACC.
  • The order of hyperthermia and radiation therapy administration does not influence therapeutic efficacy.