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Choroidal vessel density in major depressive disorder using swept-source optical coherence tomography angiography

Yan Wang1, Lei Liu2, Cong Li1

  • 1School of Medicine, South China University of Technology, Guangzhou, China; Guangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.

Journal of Affective Disorders
|October 11, 2023
PubMed

Insights

Major depressive disorder (MDD) is associated with reduced choroidal vessel density (VD), indicating potential vascular changes in the choroid. This finding suggests a link between MDD and impaired blood supply to the retina.

Area of Science:

  • Ophthalmology
  • Neuroscience
  • Vascular Biology

Background:

  • Previous research indicates retinal structural damage in major depressive disorder (MDD).
  • The choroid, crucial for retinal nourishment, is susceptible to systemic changes.
  • The impact of MDD on choroidal structure remains largely unexplored.

Purpose of the Study:

  • To investigate choroidal vessel density (VD) in patients diagnosed with MDD.
  • To utilize swept-source optical coherence tomography angiography (SS-OCTA) for precise VD measurements.
  • To explore potential correlations between MDD and choroidal vascular alterations.

Main Methods:

  • Employed SS-OCTA to assess choroidal and retinal VD in MDD patients and healthy controls (HCs).
  • MDD diagnosis confirmed using Diagnostic and International Classification of Diseases, 10th edition (ICD-10) criteria.
  • Automated calculation of VD as the ratio of vessel area to total region area.

Main Results:

  • MDD patients exhibited significantly lower supranasal and temporal choroidal vessel volume (CVV), temporal choroidal vessel volume index (CVI), and supranasal and temporal choroidal stroma volume (CSV) compared to HCs (p < 0.05).
  • Adjusted analyses revealed significant associations between reduced temporal CVV and MDD (β = -9.31, p = 0.040).
  • No significant differences in choroidal thickness or retinal VD were observed between groups (p > 0.05).

Conclusions:

  • Decreased choroidal vessel density is associated with major depressive disorder.
  • Findings suggest potential choroidal vascular impairment in MDD patients.
  • Further longitudinal studies are needed to understand the progression of these vascular changes.
Abstract

Keywords:
Choroidal vessel densityMajor depressive disorderOptical coherence tomography angiography

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