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Folding makes an imprint.

Stefan H Stricker¹

¹Reprogramming and Regeneration, Biomedical Center (BMC), Physiological Genomics, Faculty of Medicine, Ludwig Maximilian University (LMU) Munich, Planegg-Martinsried 82152, Germany; Epigenetic Epigenetic Engineering, Institute of Stem Cell Research, Helmholtz Zentrum, German Research Center for Environmental Health, Planegg-Martinsried 82152, Germany stefan.stricker@helmholtz-muenchen.de.

Genes & Development

|October 11, 2023

Summary

This summary is machine-generated.

Differences in nuclear topology precede imprinted gene expression. This study suggests parent-of-origin-specific nuclear structures may drive differential enhancer activity, influencing imprinted gene clusters like Peg13-Kcnk9.

Keywords:

chromatin structure epigenetics genomic imprinting neuron differentiation

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Area of Science:

Genomics
Epigenetics
Molecular Biology

Background:

Imprinted gene clusters exhibit parent-of-origin-dependent gene expression.
Understanding the mechanisms regulating imprinted expression is crucial for developmental biology.

Purpose of the Study:

To investigate the role of nuclear topology in the regulation of imprinted gene expression.
To explore the relationship between nuclear structure and enhancer activity at the Peg13-Kcnk9 locus.

Main Methods:

Utilized descriptive approaches, genetic manipulations, and epigenome-editing techniques.
Analyzed nuclear topology changes preceding imprinted expression.
Investigated enhancer activity in relation to genomic imprinting.

Main Results:

Demonstrated that alterations in nuclear topology occur before the onset of imprinted expression at the Peg13-Kcnk9 locus.
Provided evidence that parent-of-origin-specific nuclear structures correlate with differential enhancer activity.
Linked topological differences to parent-of-origin-specific enhancer function.

Conclusions:

Nuclear topology differences precede and potentially drive parent-of-origin-specific enhancer activity.
Suggests a model where nuclear architecture plays a key role in establishing and maintaining imprinted gene expression patterns.
Highlights the importance of three-dimensional genome organization in epigenetic regulation.