Related Experiment Video
Updated: Jul 13, 2025
06:27
Establishment of Rat Models Mimicking Gender-affirming Hormone Therapies
Published on: January 10, 2025
782
Cardiovascular disease in transgender individuals
Charlotte N Murphy1, Christian Delles1, Eleanor Davies1
1School of Cardiovascular and Metabolic Health, University of Glasgow, United Kingdom.
Atherosclerosis
|October 11, 2023
Summary
Gender-affirming hormone therapy (GAHT) may increase cardiovascular disease risk. More research is needed to understand mechanisms and guide healthcare for transgender individuals undergoing GAHT.
Area of Science:
- Endocrinology
- Cardiovascular Medicine
- Public Health
Background:
- Growing transgender population seeking gender-affirming medical care (GAHT).
- GAHT offers benefits like improved gender dysphoria and psychosocial functioning.
- Emerging evidence suggests GAHT may elevate cardiovascular disease (CVD) risk.
Purpose of the Study:
- Investigate cardiovascular health in transgender individuals.
- Understand mechanisms linking GAHT to CVD risk.
- Address research gaps in transfeminine GAHT and CVD.
Main Methods:
- Review of existing literature on GAHT and cardiovascular outcomes.
- Analysis of potential mechanisms, including hormonal effects and pathway involvement.
- Consideration of multifactorial CVD risk in the transgender population.
Main Results:
- Transmasculine GAHT (testosterone) may increase CVD risk via nitric oxide pathway, inflammation, and endothelial dysfunction.
- Research on transfeminine GAHT (estrogen) and CVD risk is critically lacking.
- Psychosocial stressors (stress, smoking, discrimination, socioeconomic status) also impact CVD risk.
Conclusions:
- Further research is crucial to elucidate GAHT's cardiovascular effects in transgender individuals.
- Understanding mechanisms is key for developing targeted healthcare and guidance.
- Addressing multifactorial risks is essential for comprehensive cardiovascular care.
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