Related Experiment Video

Updated: Jul 13, 2025

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography
06:34

Evaluation of Left Ventricular Structure and Function using 3D Echocardiography

Published on: October 28, 2020

4.0K

Three-dimensional echocardiography for the evaluation of hypertrophic cardiomyopathy patients: relation to symptoms

Isabel Cardoso1, José Miguel Viegas2, Sílvia Aguiar Rosa2

  • 1Department of Cardiology, Santa Marta Hospital, Rua de Santa Marta, n.50, Lisbon, 1169-024, Portugal. 75095@chlc.min-saude.pt.

The International Journal of Cardiovascular Imaging
|October 11, 2023
PubMed

Insights

Impaired myocardial deformation in hypertrophic cardiomyopathy patients, assessed by 3D speckle-tracking echocardiography (3DSTE), is linked to reduced functional capacity. These 3DSTE parameters offer early insights into systolic dysfunction and patient risk.

Area of Science:

  • Cardiology
  • Echocardiography
  • Cardiopulmonary Exercise Testing

Background:

  • Hypertrophic cardiomyopathy (HCM) can lead to impaired functional capacity, increasing morbidity and mortality.
  • Systolic function is a key determinant of functional capacity, and early detection of dysfunction is crucial for risk stratification.
  • Three-dimensional speckle-tracking echocardiography (3DSTE) offers advanced assessment of myocardial deformation, often revealing abnormalities before changes in ejection fraction.

Purpose of the Study:

  • To investigate the correlation between myocardial deformation parameters derived from 3DSTE and functional capacity in adult patients with HCM.
  • To determine if 3DSTE-derived parameters can identify patients with reduced exercise tolerance.

Main Methods:

  • Seventy-four adult HCM patients underwent 3DSTE and cardiopulmonary exercise testing (CPET).
  • Myocardial deformation parameters including 3D global radial strain (GRS), longitudinal strain (GLS), and circumferential strain (GCS) were measured.
  • Functional capacity was assessed by peak oxygen consumption (peak VO2) and VE/VCO2 slope.

Main Results:

  • Reduced GLS, GRS, and GCS were prevalent in the HCM population (99%, 82%, and 100% respectively).
  • 58% of patients exhibited reduced exercise tolerance (peak VO2 < 80% predicted), and 16% had impaired ventilatory efficiency.
  • Multivariable analysis revealed that 3D GLS, age, and female gender were independently associated with peak VO2. Left ventricle ejection fraction showed no significant association with peak VO2.

Conclusions:

  • Impaired myocardial deformation parameters assessed by 3DSTE are significantly associated with worse functional capacity in HCM patients.
  • 3DSTE provides valuable insights into systolic function and may help identify HCM patients at higher risk for adverse outcomes.
  • These findings highlight the utility of 3DSTE in the comprehensive evaluation of functional capacity in hypertrophic cardiomyopathy.

Keywords:
Cardiopulmonary exercise testingFunctional capacityHypertrophic cardiomyopathyLeft ventricular deformation parametersThree-dimensional speckle-tracking echocardiography

More Related Videos

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography07:11

Morphological and Functional Assessment of the Right Ventricle Using 3D Echocardiography

Published on: October 28, 2020

2.9K
Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure07:41

Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure

Published on: February 8, 2022

3.7K

Related Concept Videos

Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
16
Imaging Studies for Cardiovascular System I:Echocardiography01:17

Imaging Studies for Cardiovascular System I:Echocardiography

Cardiac imaging studies encompass a wide range of noninvasive and minimally invasive techniques designed to visualize the heart's structure and function in detail. One such technique is echocardiography, which uses high-frequency ultrasound waves to produce detailed images of the heart, known as echocardiograms.
Indications: Echocardiography is utilized to diagnose heart failure, valve disorders, and myocardial infarction. It also assesses cardiac structures' size, shape, and motion,...
345
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
9
Imaging Studies for Cardiovascular System II:Types of Echocardiography01:20

Imaging Studies for Cardiovascular System II:Types of Echocardiography

Echocardiography plays a role in assessing cardiac health and detecting heart conditions, with various types providing critical insights for diagnosis and treatment.
Types of Echocardiography
Transthoracic Echocardiography (TTE)
TTE is the most common type of echocardiogram which involves placing a transducer on the patient's chest, emitting sound waves to create heart images. TTE is invaluable for evaluating the heart's size, structure, and motion, making it particularly useful for...
281
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
11
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
37