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TWEAK Progress in Dermatology: A Review

Pramisha Kharel1, Chen Jia1, Kamal Raj Dhital2

  • 1From the Department of Rheumatology and Immunology, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, China.

Indian Journal of Dermatology
|October 12, 2023
PubMed

Insights

Tumour necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) and its receptor fibroblast growth factor-inducible 14 (Fn14) pathway are implicated in skin inflammation and autoimmune diseases. This review explores TWEAK/Fn14

Area of Science:

  • Dermatology and immunology
  • Molecular biology
  • Cellular signaling

Background:

  • Tumour necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) is a TNF superfamily member.
  • TWEAK signals through its receptor fibroblast growth factor-inducible 14 (Fn14).
  • The TWEAK/Fn14 pathway regulates cellular proliferation, angiogenesis, and inflammatory cytokine induction.

Purpose of the Study:

  • To provide an overview of the TWEAK/Fn14 pathway.
  • To review its role in cutaneous disorders.
  • To summarize therapeutic potential in dermatology.

Main Methods:

  • Literature review of case-series and open-label studies.
  • Focus on dermatological applications.

Main Results:

  • TWEAK/Fn14 pathway is present in various tissues, notably the skin.
  • This pathway is involved in the pathogenesis of inflammatory and neoplastic skin conditions.
  • Includes psoriasis, atopic dermatitis (AD), vitiligo, and melanoma.

Conclusions:

  • The TWEAK/Fn14 axis plays a significant role in skin inflammation and disease.
  • Further research into TWEAK/Fn14 modulation may offer therapeutic benefits for dermatological conditions.
Keywords:
InflammationTWEAKTWEAK/Fn14

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