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The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
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The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
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Author Spotlight: Advancing Facial Rejuvenation Therapy with Post-Laser Salicylic Acid Application
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TWEAK Progress in Dermatology: A Review.

Pramisha Kharel1, Chen Jia1, Kamal Raj Dhital2

  • 1From the Department of Rheumatology and Immunology, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, China.

Indian Journal of Dermatology
|October 12, 2023
PubMed
Summary

Tumour necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) and its receptor fibroblast growth factor-inducible 14 (Fn14) pathway are implicated in skin inflammation and autoimmune diseases. This review explores TWEAK/Fn14

Keywords:
InflammationTWEAKTWEAK/Fn14

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Area of Science:

  • Dermatology and immunology
  • Molecular biology
  • Cellular signaling

Background:

  • Tumour necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) is a TNF superfamily member.
  • TWEAK signals through its receptor fibroblast growth factor-inducible 14 (Fn14).
  • The TWEAK/Fn14 pathway regulates cellular proliferation, angiogenesis, and inflammatory cytokine induction.

Purpose of the Study:

  • To provide an overview of the TWEAK/Fn14 pathway.
  • To review its role in cutaneous disorders.
  • To summarize therapeutic potential in dermatology.

Main Methods:

  • Literature review of case-series and open-label studies.
  • Focus on dermatological applications.

Main Results:

  • TWEAK/Fn14 pathway is present in various tissues, notably the skin.
  • This pathway is involved in the pathogenesis of inflammatory and neoplastic skin conditions.
  • Includes psoriasis, atopic dermatitis (AD), vitiligo, and melanoma.

Conclusions:

  • The TWEAK/Fn14 axis plays a significant role in skin inflammation and disease.
  • Further research into TWEAK/Fn14 modulation may offer therapeutic benefits for dermatological conditions.