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A Novel Bayesian Change-point Algorithm for Genome-wide Analysis of Diverse ChIPseq Data Types
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Bayesian Trend Filtering via Proximal Markov Chain Monte Carlo.

Qiang Heng1, Hua Zhou2, Eric C Chi3

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|October 12, 2023
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Summary
This summary is machine-generated.

This study introduces epigraph priors for proximal Markov Chain Monte Carlo (MCMC), automating regularization parameter selection. This novel Bayesian approach offers a tuning-free method for complex statistical modeling.

Keywords:
Hamiltonian Monte CarloMoreau-Yosida envelopeconvex optimizationepigraphstrend filtering

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Area of Science:

  • Bayesian statistics
  • Convex optimization
  • Computational statistics

Background:

  • Proximal Markov Chain Monte Carlo (MCMC) integrates Bayesian computation and convex optimization.
  • Existing proximal MCMC methods necessitate prespecified hyperparameters and regularization parameters.
  • Nondifferentiable priors are increasingly utilized in Bayesian statistics.

Purpose of the Study:

  • To extend proximal MCMC by introducing a novel class of nondifferentiable priors: epigraph priors.
  • To develop a tuning-free proximal MCMC method for automated regularization parameter selection.
  • To apply the novel method to trend filtering, moving it from nonparametric to a parametric setting.

Main Methods:

  • Introduced epigraph priors as a new class of nondifferentiable priors.
  • Utilized the Moreau-Yosida envelope to approximate nonsmooth posterior terms.
  • Employed Hamiltonian Monte Carlo, a gradient-based MCMC sampler.
  • Applied the framework to trend filtering for posterior median fitting and uncertainty quantification.

Main Results:

  • The proposed method automates regularization parameter selection in a data-driven manner.
  • The approach allows for simultaneous calibration of mean, scale, and regularization parameters within a Bayesian framework.
  • The method demonstrated a tuning-free characteristic compared to conventional proximal MCMC techniques.
  • Successfully provided posterior median fits and credible intervals for trend filtering.

Conclusions:

  • The novel epigraph prior approach significantly advances proximal MCMC by reducing the need for manual parameter tuning.
  • This work offers a robust and automated Bayesian framework for statistical modeling involving nondifferentiable priors.
  • The method provides a powerful tool for analyzing data, particularly in settings like trend filtering, with built-in uncertainty estimation.