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A Novel Bayesian Change-point Algorithm for Genome-wide Analysis of Diverse ChIPseq Data Types
Published on: December 10, 2012
Bayesian Trend Filtering via Proximal Markov Chain Monte Carlo
Qiang Heng1, Hua Zhou2, Eric C Chi3
1Department of Statistics, North Carolina State University.
This study introduces epigraph priors for proximal Markov Chain Monte Carlo (MCMC), automating regularization parameter selection. This novel Bayesian approach offers a tuning-free method for complex statistical modeling.
Area of Science:
- Bayesian statistics
- Convex optimization
- Computational statistics
Background:
- Proximal Markov Chain Monte Carlo (MCMC) integrates Bayesian computation and convex optimization.
- Existing proximal MCMC methods necessitate prespecified hyperparameters and regularization parameters.
- Nondifferentiable priors are increasingly utilized in Bayesian statistics.
Purpose of the Study:
- To extend proximal MCMC by introducing a novel class of nondifferentiable priors: epigraph priors.
- To develop a tuning-free proximal MCMC method for automated regularization parameter selection.
- To apply the novel method to trend filtering, moving it from nonparametric to a parametric setting.
Main Methods:
- Introduced epigraph priors as a new class of nondifferentiable priors.
- Utilized the Moreau-Yosida envelope to approximate nonsmooth posterior terms.
- Employed Hamiltonian Monte Carlo, a gradient-based MCMC sampler.
- Applied the framework to trend filtering for posterior median fitting and uncertainty quantification.
Main Results:
- The proposed method automates regularization parameter selection in a data-driven manner.
- The approach allows for simultaneous calibration of mean, scale, and regularization parameters within a Bayesian framework.
- The method demonstrated a tuning-free characteristic compared to conventional proximal MCMC techniques.
- Successfully provided posterior median fits and credible intervals for trend filtering.
Conclusions:
- The novel epigraph prior approach significantly advances proximal MCMC by reducing the need for manual parameter tuning.
- This work offers a robust and automated Bayesian framework for statistical modeling involving nondifferentiable priors.
- The method provides a powerful tool for analyzing data, particularly in settings like trend filtering, with built-in uncertainty estimation.
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