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Updated: Jul 13, 2025

Integration of Bioinformatics Approaches and Experimental Validations to Understand the Role of Notch Signaling in Ovarian Cancer
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Molecular docking analysis of cetuximab with NOTCH signalling pathway targets for oral cancer

Jayanthi Pazhani1, Vishnu Priya Veeraraghavan1, Selvaraj Jayaraman1

  • 1Centre of Molecular Medicine and Diagnostics (COMManD), Department of Biochemistry, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai-600077, India.

Bioinformation
|October 12, 2023
PubMed

Insights

Cetuximab may target NOTCH signaling pathways, including NOTCH1, NICD, and HES1, offering potential for oral squamous cell carcinoma treatment. This approach could suppress tumor invasion and metastasis.

Area of Science:

  • Molecular biology
  • Oncology
  • Cell signaling

Background:

  • Notch signaling is crucial in cell communication and cancer development.
  • NOTCH pathway mutations are common in oral squamous cell carcinoma (OSCC).

Purpose of the Study:

  • To investigate the molecular docking of cetuximab with NOTCH signaling targets.
  • To explore cetuximab's potential in treating OSCC by targeting NOTCH.

Main Methods:

  • Molecular docking analysis was performed.
  • Interactions between cetuximab and NOTCH1, NICD, and HES1 were simulated.

Main Results:

  • Cetuximab showed potential binding interactions with NOTCH1, NICD, and HES1.
  • The findings suggest cetuximab can modulate the NOTCH pathway.

Conclusions:

  • Targeting NOTCH signaling with cetuximab may inhibit invasion and metastasis in OSCC.
  • Cetuximab presents a potential therapeutic strategy for oral carcinoma.
Keywords:
CetuximabNOTCH signalingOral carcinomamolecular docking

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