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Hepatic abscess due to Candida species in neonates: Case reports in Vietnam

Thi Quynh Nga Nguyen1,2, Thi Van Nguyen1, Thao Nguyen Pham1,2

  • 1Hanoi Medical University, Viet Nam.

Idcases
|October 12, 2023
PubMed

Insights

Neonatal hepatic abscess (NHA), a serious condition, can be caused by fungi like Candida. This study highlights three cases of fungal NHA, emphasizing diagnostic and treatment challenges in neonates.

Area of Science:

  • Medical Mycology
  • Neonatal Medicine
  • Pediatric Infectious Diseases

Background:

  • Neonatal hepatic abscess (NHA) is a severe, often fatal, condition affecting newborns.
  • While bacterial causes are common, fungal NHA, particularly Candida species, presents unique diagnostic and therapeutic challenges.
  • Understanding the etiology and associated factors of NHA is crucial for timely intervention.

Observation:

  • This report details three distinct cases of neonatal hepatic abscess caused by Candida species.
  • Each case involved different underlying conditions contributing to the development of the fungal abscess.
  • The clinical presentations and diagnostic pathways varied across the presented cases.

Findings:

  • Fungal NHA, though rare, represents a significant clinical concern in neonates.
  • Candida species are an important, albeit uncommon, cause of neonatal hepatic abscess.
  • The presence of diverse underlying pathologies complicates the management of fungal NHA.

Implications:

  • Early recognition and diagnosis of fungal NHA are critical for improving neonatal outcomes.
  • Tailored treatment strategies addressing both the fungal infection and underlying causes are necessary.
  • Further research into the pathogenesis and effective management of fungal NHA in neonates is warranted.
Keywords:
Fungal infectionHepatic abscessNeonatesPrematurity

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